LEAKAGE OF ENZYMES FROM DENERVATED AND DYSTROPHIC CHICKEN MUSCLE
LEAKAGE OF ENZYMES FROM DENERVATED AND DYSTROPHIC CHICKEN MUSCLE
复制标题
DOI：
10.1001/archneur.1966.00470090093013
复制
发表时间：
1966-01-01
影响因子：
--
通讯作者：
DAWSON, DM
中科院分区：
文献类型：
--
作者：
DAWSON, DM
测定了5种细胞质酶在生理盐水中的出肌速率。结果发现，尽管分子量和组织浓度变化很大，但测量的所有酶都以大致相同的速率离开肌肉。来自肌营养不良症纯合子鸡的肌肉显示出渗漏率增加，这同样适用于所有酶。正在经历神经性萎缩的肌肉也比正常肌肉更容易渗透酶，并且比营养不良的肌肉更容易渗透。本文还讨论了血清酶升高的可能控制因素。
The rates of exit of 5 cytoplasmic enzymes from chicken biceps muscle into a physiological salt solution were measured. It was found that all the enzymes measured left the muscle at approximately the same rate, in spite of wide variation in molecular weight and tissue concentration. Muscle from chickens homozygous for muscular dystrophy showed an increased rate of leakage, which applied equally to all the enzymes. Muscle which was undergoing neurogenic atrophy was also more permeable to enzymes than normal and was more permeable than dystrophic muscle. Some possible controlling factors in the elevation of serum enzymes are discussed.