Mesostructured multifunctional nanoparticles for imaging and drug delivery
Mesostructured multifunctional nanoparticles for imaging and drug delivery
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DOI：
10.1039/b902462j
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发表时间：
2009-01-01
影响因子：
--
通讯作者：
Zink, Jeffrey I.
中科院分区：
文献类型：
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作者：
Liong, Monty;Angelos, Sarah;Zink, Jeffrey I.
通过表面活性剂模板化溶胶-凝胶技术制备的介孔结构二氧化硅颗粒（直径类似于100 nm，孔类似于2 nm）是通用载体，其可以容易地用活性分子衍生化以产生多功能材料。通过有意地将活性分子放置在介观结构的不同区域中，荧光分子、分子机器、靶向配体和金属纳米晶体可以组合在单个颗粒上。本文综述了将多种组分引入到介孔二氧化硅上，用于同时成像和传递分子的生物学应用的研究。
Mesostructured silica particles (similar to 100 nm diameter with similar to 2 nm pores) prepared by surfactant-templated sol-gel techniques are versatile supports that can be easily derivatized with active molecules to create multifunctional materials. By deliberately placing active molecules in different regions of the mesostructure, fluorescent molecules, molecular machines, targeting ligands, and metal nanocrystals can be combined on a single particle. This review highlights the research in which multiple components are incorporated onto mesoporous silica for simultaneous imaging and delivery of molecules in biological applications.