Planar cell polarity: coordinating morphogenetic cell behaviors with embryonic polarity.

Planar cell polarity: coordinating morphogenetic cell behaviors with embryonic polarity.
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DOI:
10.1016/j.devcel.2011.06.011
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发表时间:
2011-07-19
期刊:
影响因子:
11.8
通讯作者:
Solnica-Krezel, Lilianna
Solnica-Krezel, Lilianna
中科院分区:
生物学1区
文献类型:
--
作者:
Gray, Ryan S.;Roszko, Isabelle;Solnica-Krezel, Lilianna

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平面细胞极化需要在组织平面内建立细胞不对称。平面细胞极性(Planar Cell Polarity, PCP)信号系统是一种进化保守的信号系统,它的核心成分(包括frizzed、Van Gogh、Flamingo、Prickle和disheveled)之间通过细胞内和细胞间的反馈相互作用,建立了它们特有的不对称细胞内分布和细胞群体的协调平面极性。通过将全局模式信息转化为细胞膜和胞内细胞器的不对称性,PCP信号通过胚胎极性协调单个细胞和细胞群体的形态发生行为。在脊椎动物中,PCP信号通过使节点/库普弗氏囊中的纤毛极化,将胚胎前后极性与左右极性联系起来。
Planar cell polarization entails establishment of cellular asymmetries within the tissue plane. An evolutionarily conserved Planar Cell Polarity (PCP) signaling system employs intra- and intercellular feedback interactions between its core components, including Frizzled, Van Gogh, Flamingo, Prickle and Dishevelled, to establish their characteristic asymmetric intracellular distributions and coordinate planar polarity of cell populations. By translating global patterning information into asymmetries of cell membranes and intracellular organelles, PCP signaling coordinates morphogenetic behaviors of individual cells and cell populations with the embryonic polarity. In vertebrates, by polarizing cilia in the node/Kupffer’s vesicle, PCP signaling links the anteroposterior to left-right embryonic polarity.
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