Direct Compression Tablet Containing 99% Active Ingredient-A Tale of Spherical Crystallization
Direct Compression Tablet Containing 99% Active Ingredient-A Tale of Spherical Crystallization
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DOI：
10.1016/j.xphs.2018.11.015
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发表时间：
2019-04-01
影响因子：
3.8
通讯作者：
Sun, Changquan Calvin
中科院分区：
文献类型：
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作者：
Chen, Hongbo;Aburub, Aktham;Sun, Changquan Calvin
直接压片(DC)是最简单、最具成本效益的片剂生产工艺，因为它只涉及混合和压片。然而，活性药物成分通常表现出较差的机械和微晶性能，这就需要稀释和使用高比例的辅料来实现稳健的DC制造工艺。因此，DC片剂中的载药量通常较低(通常
Direct compression (DC) is the easiest and most cost-effective process for tablet manufacturing, because it only involves blending and compression. However, active pharmaceutical ingredients generally exhibit poor mechanical and micromeritic properties, which necessitate dilution and the use of high percentage of excipients to enable a robust DC manufacturing process. Consequently, drug loading in DC tablets is usually low (typically