Genetic polymorphism of vitamin K epoxide reductase (VKORC1) 1173C>T in a Chinese and a Caucasian population
Genetic polymorphism of vitamin K epoxide reductase (VKORC1) 1173C>T in a Chinese and a Caucasian population
复制标题
DOI：
10.1111/j.1742-7843.2006.pto_440.x
复制
发表时间：
2006-06-01
影响因子：
3.1
通讯作者：
Becquemont, Laurent
中科院分区：
文献类型：
--
作者：
Larramendy-Gozalo, Claire;Yang, Jue Quin;Becquemont, Laurent
本文介绍了一项研究，调查遗传多态性在维生素K环氧化物还原酶基因在口服抗凝剂反应中的作用。结果表明，种族是决定维持口服抗凝剂剂量需求的重要因素。已经证实，维生素K环氧化物还原酶基因的改变可以改变中国人和高加索人口服抗凝剂剂量的个体间和种族间的需求。
The article presents a study that investigates the role of genetic polymorphism within the vitamin K epoxide reductase gene in the response to oral anticoagulants. Results show that ethnicity is a significant factor in determining maintenance of oral anticoagulants dose requirements. It has been confirmed that changes in the vitamin K epoxide reductase gene could alter the requisites of oral anticoagulant dosage interindividually and interethnically between Chinese and Caucasians.