Green Synthesis of Gold Nanoparticles Using Glycerol-Incorporated Nanosized Liposomes
Green Synthesis of Gold Nanoparticles Using Glycerol-Incorporated Nanosized Liposomes
复制标题
DOI：
10.1021/la201771s
复制
发表时间：
2011-09-06
期刊：
影响因子：
3.9
通讯作者：
O'Sullivan, Ciara K.
中科院分区：
文献类型：
--
作者：
Genc, Ruekan;Clergeaud, Gael;O'Sullivan, Ciara K.
在过去的十年中，由于金属纳米粒子的独特性质和在催化、电子、等离子体和传感领域的广泛应用，人们对其无机合成所需尺寸和形状的方法产生了巨大的兴趣。在这里，我们报告了一种环境友好的，一锅合成金属纳米粒子，它避免了使用有机溶剂，并且需要温和的实验条件。所开发的方法使用脂质体作为纳米反应器，脂质体通过包封氯金酸制备，并利用甘油作为还原剂，结合在脂质双分子层及其亲水核心中，用于控制制备高度均匀的金纳米粒子群。研究了温度、封盖剂的存在和甘油浓度对纳米颗粒大小和均匀性的影响，并与基于溶液的甘油介导的纳米颗粒合成进行了比较。在所设计的脂质体纳米反应器中，制备了分布均匀的2-8 nm范围内的金纳米粒子，其大小与甘油浓度、温度和封盖剂的存在密切相关，而在没有脂质体的情况下，获得了大而不均匀的无定形纳米粒子群。用透射电镜成像分析了颗粒形态和大小，用光子相关光谱测量了脂质体的大小。
There has been enormous interest in the last decade in development methods for the inorganic synthesis of metallic nanopartides of desired sizes and shapes because of their unique properties and extensive applications in catalysis, electronics, plasmonics, and sensing. Here we report on an environmentally friendly, one-pot synthesis of metallic nanoparticles, which avoids the use of organic solvents and requires mild experimental conditions. The developed method uses liposomes as nanoreactors, where the liposomes were prepared by encapsulating chloroauric acid and exploited the use of glycerol, incorporated within the lipid bilayer as well as in its hydrophilic core, as a reducing agent for the controlled preparation of highly homogeneous populations of gold nanopartides. The effects of temperature, the presence of a capping agent, and the concentration of glycerol on the size and homogeneity of the nanoparticles formed were investigated and compared with solution-based glycerol-mediated nanoparticle synthesis. Well-distributed gold nanoparticle populations in the range of 2-8 nm were prepared in the designed liposomal nanoreactor with a dear dependence of the size on the concentration of glycerol, the temperature, and the presence of a capping agent whereas large, heterogeneous populations of nanopartides with amorphous shapes were obtained in the absence of liposomes. The particle morphology and sizes were analyzed using transmission electron microscopy imaging, and the liposome size was measured using photon correlation spectroscopy.