Lateral gene transfer (LGT) between Archaea and Escherichia coli is a contributor to the emergence of novel infectious disease.
Lateral gene transfer (LGT) between Archaea and Escherichia coli is a contributor to the emergence of novel infectious disease.
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DOI：
10.1186/1471-2334-3-13
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发表时间：
2003-06-19
影响因子：
3.7
通讯作者：
Faguy, DM
中科院分区：
文献类型：
--
作者：
Faguy, DM
横向基因转移是病原菌获得新毒力基因的主要机制。最近的全基因组分析表明，大规模的基因转移之间的差异很大的生物体。类古细菌基因作为毒力基因存在于多种病原菌中，其基因组中含有大量功能未知的类古细菌基因。由于它们非常不同的进化历史和不同的环境，它们为细菌病原体提供了一个潜在的毒力基因库。我们可以通过以下方法来验证这一假设：1）鉴定可能已经转移（直接或间接）到E。coli O157：H7; 2）调查病原体和非病原体中相似基因的分布，以及3）对假定的转移进行严格的系统发育分析。虽然这一假说主要集中在古生菌和E.大肠杆菌，它将作为一个模型，具有广泛的适用性，以一些致病系统。由于没有古细菌是已知的脊椎动物病原体，古细菌样转移基因与细菌中的毒力代表了毒力基因出现的明确模式。
Lateral gene transfer is the major mechanism for acquisition of new virulence genes in pathogens. Recent whole genome analyses have suggested massive gene transfer between widely divergent organisms. Archeal-like genes acting as virulence genes are present in several pathogens and genomes contain a number of archaeal-like genes of unknown function. Archaea, by virtue of their very different evolutionary history and different environment, provide a pool of potential virulence genes to bacterial pathogens. We can test this hypothesis by 1)identifying genes likely to have been transferred (directly or indirectly) to E. coli O157:H7 from archaea; 2)investigating the distribution of similar genes in pathogens and non-pathogens and 3)performing rigorous phylogenetic analyses on putative transfers. Although this hypothesis focuses on archaea and E. coli, it will serve as a model having broad applicability to a number of pathogenic systems. Since no archaea are known vertebrate pathogens, archaeal-like transferred genes that are associated with virulence in bacteria represent a clear model for the emergence of virulence genes.
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影响因子：
9.2
作者：
Faguy, DM
通讯作者：
Faguy, DM
影响因子：
2.8
作者：
Jakubovics, NS;Smith, AW;Jenkinson, HF
通讯作者：
Jenkinson, HF
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3.1
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Manca, C;Paul, S;Kaplan, G
通讯作者：
Kaplan, G
影响因子：
3.2
作者：
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Steinman, HM
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14.9
作者：
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通讯作者：
Blattner, FR