Effect of implantation site and injury condition on host response to human-derived fascia lata ECM in a rat model.
Effect of implantation site and injury condition on host response to human-derived fascia lata ECM in a rat model.
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植入部位和损伤条件对大鼠模型中人源阔筋膜 ECM 宿主反应的影响。
DOI：
10.1002/jor.21529
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Derwin,KathleenA
中科院分区：
文献类型：
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作者：
Leigh,DianeR;Baker,AndrewR;Mesiha,Mena;Rodriguez,ERene;Tan,CarmelaD;Walker,Esteban;Derwin,KathleenA
ECM支架的宿主反应和重塑被认为是修复或重建过程成功或失败的关键决定因素。在皮下或腹壁植入模型中研究了宿主反应。在原位部位评价预期用于肌腱或韧带修复的ECM对宿主反应的程度尚不清楚。本研究比较了大鼠模型中不同植入部位对人源阔筋膜ECM的宿主反应。结果表明，大鼠肩关节异种移植物与体壁异种移植物在7天时没有表现出不同的宿主反应，这表明两个部位都适合研究生物移植物的早期宿主反应以及各种旨在改变早期宿主反应的治疗效果。到第28天，大鼠肩部的异种移植物确实引起了与体壁中所见不同的独特宿主反应。因此，使用原位肩关节模型来研究肩袖修复所用生物移植物的长期宿主反应和重塑可能更合适。© 2011 Orthopathy Research Society由Wiley Periodicals，Inc.出版。J Orthop Res 30：461-467，2012
The host response and remodeling of ECM scaffolds are believed to be critical determinants of success or failure in repair or reconstructive procedures. Host response has been investigated in subcutaneous or abdominal wall implantation models. The extent to which evaluation of the host response to ECM intended for tendon or ligament repair should be performed in an orthotopic site is not known. This study compared the host response to human‐derived fascia lata ECM among various implantation sites in the rat model. Results showed that a xenograft in the rat shoulder does not exhibit a different host response at 7 days from xenograft in the body wall, suggesting that either site may be appropriate to study theearly host response to biologic graftsas well as theeffect of various treatmentsaimed to modify the early host response. By 28 days, a xenograft in the rat shoulder does elicit a unique host response from that seen in the body wall. Therefore, it may be more appropriate to use an orthotopic shoulder model for investigating thelong‐term host response and remodelingof biologic grafts to be used for rotator cuff repair. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:461–467, 2012