Luteolin reduces migration of human glioblastoma cell lines via inhibition of the p-IGF-1R/PI3K/AKT/mTOR signaling pathway.
Luteolin reduces migration of human glioblastoma cell lines via inhibition of the p-IGF-1R/PI3K/AKT/mTOR signaling pathway.
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DOI：
10.3892/ol.2017.6643
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发表时间：
2017-09
期刊：
影响因子：
2.9
通讯作者：
Pan H
中科院分区：
文献类型：
--
作者：
Wang Q;Wang H;Jia Y;Ding H;Zhang L;Pan H
木犀草素（3′，4′，5,7-四羟基黄酮）是一种常见的膳食类黄酮，在多种癌症模型中已被证明具有抗癌作用。然而，木犀草素抑制胶质母细胞瘤细胞转移的具体机制尚不清楚。本研究评估了木犀草素对U251MG和U87MG人胶质母细胞瘤细胞系的影响。木犀草素处理可显著抑制胶质母细胞瘤细胞的迁移，这种作用与基质金属蛋白酶(MMP)-2、MMP-9下调和组织金属蛋白酶抑制剂(TIMP)-1、TIMP-2上调有关。此外，木犀草素还能抑制上皮-间质过渡相关表型。此外，磷酸化的胰岛素样生长因子-1受体/磷酸肌肽3激酶/蛋白激酶B/哺乳动物雷帕霉素靶点（p-IGF-1R/PI3K/AKT/mTOR）信号通路被证明参与了这些过程。本研究结果表明，黄酮类木犀草素通过改变p-IGF-1R/PI3K/AKT/mTOR的激活来减少胶质母细胞瘤细胞的迁移，并可能在临床环境中具有潜在的化学预防应用。
Luteolin (3′,4′,5,7-tetrahydroxyflavone) is a common dietary flavonoid, which has been demonstrated to exert anticancer effects in multiple cancer models. However, the detailed mechanisms underlying the inhibitory effect of luteolin on glioblastoma cell metastasis remain poorly understood. The present study assessed the effects of luteolin in the U251MG and U87MG human glioblastoma cell lines. Luteolin treatment significantly inhibited glioblastoma cell migration, and this effect was associated with downregulated matrix metalloproteinase (MMP)-2, MMP-9 and upregulated tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2. In addition, luteolin also inhibited the epithelial-mesenchymal transition-associated phenotype. Furthermore, the phosphorylated insulin-like growth factor-1 receptor/phosphoinositide 3 kinase/protein kinase B/mammalian target of rapamycin (p-IGF-1R/PI3K/AKT/mTOR) signaling pathway was demonstrated to participate in these processes. The results of the present study demonstrated that the flavonoid luteolin reduced the migration of glioblastoma cells by altering p-IGF-1R/PI3K/AKT/mTOR activation, and may have potential applications for chemoprevention in a clinical setting.
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影响因子：
11.8
作者：
King, Helen;Aleksic, Tamara;Haluska, Paul;Macaulay, Valentine M.
通讯作者：
Macaulay, Valentine M.
影响因子：
64.5
作者：
Hiraoka, N;Allen, E;Weiss, SJ
通讯作者：
Weiss, SJ
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DOI：
10.1016/j.bbrc.2014.04.039
发表时间：
2014-05-16
影响因子：
3.1
作者：
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通讯作者：
Tang, Xiuwen
影响因子：
2.8
作者：
Lu, Kung-Wen;Chen, Jung-Chou;Chung, Jing-Gung
通讯作者：
Chung, Jing-Gung
影响因子：
3.7
作者：
Wojtalla A;Salm F;Christiansen DG;Cremona T;Cwiek P;Shalaby T;Gross N;Grotzer MA;Arcaro A
通讯作者：
Arcaro A