Mechanisms, organisms and markers of infection in pregnancy
Mechanisms, organisms and markers of infection in pregnancy
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DOI：
10.1016/s0165-0378(02)00018-9
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发表时间：
2002-10-01
影响因子：
3.4
通讯作者：
Robins-Browne, R
中科院分区：
文献类型：
--
作者：
Garland, SM;Chuileann치in, FN;Robins-Browne, R
早产仍然是产科的一个重大问题。它有多种原因，其中约50%被认为是由感染引起的。值得注意的是，感染作为一种发病机制更可能发生在妊娠< 30周的早产儿中，并且在很大程度上是亚临床的。潜在的病原体主要来自上升路线和内源性阴道菌群，引起绒毛膜羊膜炎。来自这些病原体的内毒/外毒素的释放、炎症细胞因子通路、前列腺素、金属蛋白酶的刺激和产生所导致的发病率包括产妇败血症（绒毛膜羊膜炎、败血症、产后子宫内膜炎）、早产（婴儿早产及其后果、脑瘫和新生儿败血症易感性增加）。此外，感染还会增加因胎儿丢失（极度早产）和严重新生儿败血症而导致的死亡率。(C) 2002爱思唯尔科学爱尔兰有限公司版权所有。
Premature delivery is still a significant problem in Obstetrics. It has multiple causes, with around 50% thought due to infection. Of note infection as a pathogenesis is more likely in those pre-term births occurring < 30 weeks gestation and is largely sub-clinical. Potential pathogens largely arise from the ascending route and from the endogenous vaginal flora, causing chorioamnionitis. Resultant morbidity from the release of endo + /exotoxins from such pathogens, the stimulation and production of inflammatory cytokine pathways, prostaglandins, metalloproteinases includes maternal sepsis (chorioamnionitis, septicaemia, post-partum endometritis), pre-term delivery (infant pre-maturity and its consequences, increased susceptibility to cerebral palsy and neonatal sepsis). As well, infection increases mortality due to fetal loss (extreme pre-maturity) as well as severe neonatal sepsis. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.