The platelet as a model system for the acute actions of nuclear receptors
The platelet as a model system for the acute actions of nuclear receptors
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DOI：
10.1016/j.steroids.2009.09.005
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发表时间：
2010-08-01
期刊：
影响因子：
2.7
通讯作者：
Bishop-Bailey, David
中科院分区：
文献类型：
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作者：
Bishop-Bailey, David
血小板是循环中的细胞碎片，在血栓形成中起关键作用，其活性与心血管疾病、糖尿病、炎症和癌细胞转移的进展有关。最近，在人的血小板上发现了许多核受体，包括性激素和糖皮质激素的受体，以及过氧化物酶体增殖物激活受体S和维甲酸X受体S。虽然血小板不含核，但这些受体的选择性配体激活了它们各自的核受体，调节血小板的聚集和激活。因此，人类血小板由于其丰度和可获得性，是研究核受体快速非基因组机制的极好的模型系统。此外，由于靶向血小板是一个主要的临床治疗领域，对血小板核受体的分析可能为新的药物靶点提供线索，并提供关于核受体在循环中的生理作用的重要信息。(C)2009 Elsevier Inc.保留所有权利。
Platelets are circulating cell fragments which play a critical role in thrombosis, and whose activity is associated with the progress of cardiovascular diseases, diabetes, inflammation, and cancer cell metastasis. Recently, a number of nuclear receptors have been found present in human platelets, including the receptors for sex steroids, and glucocorticoids, along with peroxisome proliferator-activated receptors (PPAR)s and retinoid X receptors (RXR)s. Although the platelet contains no nucleus, selective ligands for these receptors activate their respective platelet nuclear receptors and regulate platelet aggregation and activation. The human platelet, because of its abundance and accessibility therefore represents an excellent model system to study the rapid non-genomic mechanism of nuclear receptors. Moreover, since targeting platelets is a major clinical therapeutic area, analysis of platelet nuclear receptors may provide clues for new drug targets as well as provide important information regarding the physiological roles of nuclear receptors in the circulation. (C) 2009 Elsevier Inc. All rights reserved.