Host immunity to Plasmodium infection: Contribution of Plasmodium berghei to our understanding of T cell-related immune response to blood-stage malaria
Host immunity to Plasmodium infection: Contribution of Plasmodium berghei to our understanding of T cell-related immune response to blood-stage malaria
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DOI：
10.1016/j.parint.2022.102646
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发表时间：
2022-09-08
影响因子：
1.9
通讯作者：
Inoue，Shin-Ichi
中科院分区：
文献类型：
--
作者：
Ibraheem，Yarob;Bayarsaikhan，Ganchimeg;Inoue，Shin-Ichi
疟疾是一种由感染疟原虫引起的危及生命的疾病。尽管进行了数十年的大规模研究工作，但开发有效疟疾疫苗的目标仍未实现。CD4+辅助T细胞、CD8+细胞毒性T细胞和γδT细胞与对肝期和血液期疟原虫感染的免疫反应有关。T细胞系对疟原虫感染的免疫应答与免疫保护性和免疫病理学有关。对疟疾小鼠模型的研究有助于我们理解宿主的免疫反应。本文主要介绍了伯氏疟原虫血液期感染的小鼠疟疾模型，并回顾了我们对抗疟原虫感染的T细胞免疫应答的认识。此外，我们还讨论了实验人体研究的结果。通过使用带有线形疟原虫的疟疾小鼠模型进行进一步的研究，可以揭示T细胞介导的对疟疾感染的确切免疫机制。这些发现对于推动开发有效的疟疾疫苗的努力将是非常宝贵的。
Malaria is a life-threatening disease caused by infection withPlasmodiumparasites. The goal of developing an effective malaria vaccine is yet to be reached despite decades of massive research efforts. CD4+helper T cells, CD8+cytotoxic T cells, and γδ T cells are associated with immune responses to both liver-stage and blood-stagePlasmodiuminfection. The immune responses of T cell-lineages toPlasmodiuminfection are associated with both protection and immunopathology. Studies with mouse model of malaria contribute to our understanding of host immune response. In this paper, we focus primarily on mouse malaria model with blood-stagePlasmodium bergheiinfection and review our knowledge of T cell immune responses againstPlasmodiuminfection. Moreover, we also discuss findings of experimental human studies. Uncovering the precise mechanisms of T cell-mediated immunity toPlasmodiuminfection can be accomplished through further investigations using mouse models of malaria with rodentPlasmodiumparasites. Those findings would be invaluable to advance the efforts for development of an effective malaria vaccine.