Asthma in humans and cats: is there a common sensitivity to aeroallegens in shared environments?
Asthma in humans and cats: is there a common sensitivity to aeroallegens in shared environments?
复制标题
人类和猫的哮喘：在共同的环境中对空气过敏原是否存在共同的敏感性？
DOI：
10.1016/j.envres.2009.02.001
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发表时间：
2009
影响因子：
8.3
通讯作者：
Rabinowitz,Peter
中科院分区：
文献类型：
--
作者：
Reinero,CarolR;DeClue,AmyE;Rabinowitz,Peter
猫会自发地发生嗜酸性呼吸道炎症和呼吸道高反应性，这与人类过敏性哮喘非常相似。此外，家猫与人类一样暴露在空气过敏原的环境中。我们回顾了关于猫哮喘的病理生理学的科学文献，包括与人类哮喘的相似之处以及关于环境空气过敏原触发因素的证据。病理生理学研究结果表明，人类和猫对吸入性变应原的反应有重要的相似之处。只有几项研究考察了环境空气过敏原对猫疾病的发展。有限的证据表明，一些环境过敏原可以导致猫和人类的疾病。似乎有必要在人类和动物卫生专业人员之间就哮喘的环境原因进行更多的沟通。具体地说，利用分子技术和临床流行病学方法对人和猫哮喘之间的联系进行更多研究，可能有助于更好地了解环境风险。最后，应该考虑在新的治疗干预措施的临床前试验中使用自然感染和/或实验诱导(使用临床相关过敏原)的哮喘猫。
Cats spontaneously develop eosinophilic airway inflammation and airway hyperreactivity that is very similar to human allergic asthma. In addition, household cats share environmental exposures to aeroallergens with humans. We review the scientific literature concerning the pathophysiology of feline asthma, including similarities to human asthma and evidence regarding environmental aeroallergen triggers. Results of pathophysiological studies suggest important similarities between human and feline responses to inhaled allergens. Only a few studies were found that examined the development of disease in cats to environmental aeroallergens. Limited evidence suggests that some environmental allergens can cause disease in both cats and humans. It appears that there is a need for greater communication between human and animal health professionals regarding environmental causes of asthma. Specifically, additional research into linkages between human and feline asthma using both molecular techniques and clinical epidemiological approaches could lead to improved understanding of the environmental risks. Finally, there should be consideration of use of naturally affected and/or experimentally induced (using clinically relevant allergens) asthmatic cats in preclinical trials for novel therapeutic interventions.