A new method for topology design of electromagnetic antennas in hyperthermia therapy
A new method for topology design of electromagnetic antennas in hyperthermia therapy
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DOI：
10.1016/j.apm.2016.10.010
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发表时间：
2017-02-01
影响因子：
5
通讯作者：
Novotny, Antonio A.
中科院分区：
文献类型：
--
作者：
Amad, Alan A. S.;Loula, Abimael F. D.;Novotny, Antonio A.
拓扑导数的概念在拓扑优化、反问题、图像处理、多尺度本构建模、断裂力学和损伤演化建模等领域有着广泛的应用。在这项工作中，我们开发了一种新的优化方法的基础上的拓扑衍生物的概念应用于癌症治疗的热疗。热疗是一种非侵入性的医学治疗，其中通过电磁波人工加热身体组织，将热量集中在正在进行凋亡的癌细胞中。因此，基本思想在于找到由电磁天线产生的热源的分布，旨在增加肿瘤所占据的区域的温度，同时保持身体其余部分的温度。数值结果说明可能的应用所提出的方法来治疗癌症的热疗。(C)2016 Elsevier Inc. All rights reserved.
The topological derivative concept has been proved to be useful in many relevant applications such as topology optimization, inverse problems, image processing, multi-scale constitutive modeling, fracture mechanics and damage evolution modeling. In this work, we develop a new optimization method based on the topological derivative concept applied to the cancer treatment by hyperthermia. Hyperthermia therapy is a non-invasive medical treatment in which body tissue is artificially heated through electromagnetic waves, focusing the heat in cancerous cells undergoing apoptosis. The basic idea, therefore, consists in finding a distribution of heat source generated by electromagnetic antenna aiming to increase the temperature in the region occupied by the tumor, while keeping the temperature in the remainder part of the body. Numerical results are presented illustrating possible application of the proposed methodology to treatment of cancer by hyperthermia. (C) 2016 Elsevier Inc. All rights reserved.