Multiparametric Ultrasound for Prostate Cancer Detection and Localization: Correlation of B-mode, Shear Wave Elastography and Contrast Enhanced Ultrasound with Radical Prostatectomy Specimens
Multiparametric Ultrasound for Prostate Cancer Detection and Localization: Correlation of B-mode, Shear Wave Elastography and Contrast Enhanced Ultrasound with Radical Prostatectomy Specimens
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DOI：
10.1097/ju.0000000000000415
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发表时间：
2019-12-01
影响因子：
6.6
通讯作者：
Salomon, Georg
中科院分区：
文献类型：
--
作者：
Mannaerts, Christophe K.;Wildeboer, Rogier R.;Salomon, Georg
目的：与多参数磁共振成像类似，多参数超声是前列腺癌成像的一种有前途的方法。我们使用根治性前列腺切除术组织病理学作为参考标准，确定了B型、剪切波弹性成像和超声造影定量软件以及组合、多参数超声对临床显著前列腺癌定位的诊断性能。材料和方法：从2017年5月至2017年7月，50例经活检证实的前列腺癌男性在根治性前列腺切除术前在1家中心接受了多参数超声检查。三名阅片人独立评价了12个感兴趣解剖区域，以确定所有单独超声模式和多参数超声在5分Likert量表上发生临床显著前列腺癌的可能性。使用逻辑线性混合模型估计临床显著前列腺癌（任何Gleason评分3 + 4 = 7或更高、肿瘤体积0.5 ml或更大、前列腺外扩展或pN1期的肿瘤）定位的诊断性能，使用Likert评分3或更高和4或更高作为阈值。为了检测指标病变的读者选择了2个最可疑的区域interests.Results：共48名男子被列入最后的分析。多参数超声（Likert 3或以上）对临床显著前列腺癌的感兴趣区域特异性灵敏度为74%（95% CI 67 - 80），而B型、剪切波弹性成像和对比增强超声分别为55%（95% CI 47 - 63）、55%（95% CI 47 - 63）和59%（95% CI 51 - 67）。多参数超声敏感性显著高于Likert阈值和所有不同临床显著前列腺癌定义（所有p
Purpose: Similar to multiparametric magnetic resonance imaging, multiparametric ultrasound represents a promising approach to prostate cancer imaging. We determined the diagnostic performance of B-mode, shear wave elastography and contrast enhanced ultrasound with quantification software as well as the combination, multiparametric ultrasound, for clinically significant prostate cancer localization using radical prostatectomy histopathology as the reference standard.Materials and Methods: From May 2017 to July 2017, 50 men with biopsy proven prostate cancer underwent multiparametric ultrasound before radical prostatectomy at 1 center. Three readers independently evaluated 12 anatomical regions of interest for the likelihood of clinically significant prostate cancer on a 5-point Likert scale for all separate ultrasound modalities and multiparametric ultrasound. A logistic linear mixed model was used to estimate diagnostic performance for the localization of clinically significant prostate cancer (any tumor with Gleason score 3 + 4 = 7 or greater, tumor volume 0.5 ml or greater, extraprostatic extension or stage pN1) using a Likert score of 3 or greater and 4 or greater as the threshold. To detect the index lesion the readers selected the 2 most suspicious regions of interest.Results: A total of 48 men were included in the final analysis. The region of interest specific sensitivity of multiparametric ultrasound (Likert 3 or greater) for clinically significant prostate cancer was 74% (95% CI 67-80) compared to 55% (95% CI 47-63), 55% (95% CI 47-63) and 59% (95% CI 51-67) for B-mode, shear wave elastography and contrast enhanced ultrasound, respectively. Multiparametric ultrasound sensitivity was significantly higher for Likert thresholds and all different clinically significant prostate cancer definitions (all p