Two-dimensional FT-ICR/MS with IRMPD as fragmentation mode
Two-dimensional FT-ICR/MS with IRMPD as fragmentation mode
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DOI：
10.1016/j.ijms.2010.10.034
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发表时间：
2011-09-15
影响因子：
1.8
通讯作者：
Rolando, Christian
中科院分区：
文献类型：
--
作者：
van Agthoven, Maria A.;Delsuc, Marc-Andre;Rolando, Christian
1988年，Gaumann等人引入了一种用于二维FT-ICR/MS的脉冲序列，该脉冲序列将母离子和碎片离子相关联，而无需离子分离。计算机技术的进步使得这种脉冲序列在分析上有用，以便获得复杂样品的结构信息。脉冲序列可以应用于所有回旋加速器半径相关的碎裂模式，包括无气体碎裂模式，如IRMPD，其不影响灵敏度和分辨能力，就像气体脉冲进入ICR室一样。该研究表明了二维FT-ICR/MS的可行性，并为将该方法转化为可行的分析工具奠定了基础。(C)2010爱思唯尔有限公司版权所有。
In 1988, Gaumann et al. introduced a pulse sequence for two-dimensional FT-ICR/MS correlating parent ions and fragment ions without the need for ion isolation. The improvement in computer technology makes this pulse sequence analytically useful in order to obtain structural information on complex samples. The pulse sequence can be applied to all cyclotron radius-dependent fragmentation modes, including gas-free fragmentation modes like IRMPD, which do not affect sensitivity and resolving power like the pulsing of a gas into the ICR cell does. This study shows the feasibility of 2D FT-ICR/MS and lays the groundwork to turn this method into a viable analytical tool. (C) 2010 Elsevier B.V. All rights reserved.