Prenatal withdrawal from opiates interferes with hatching of otherwise viable chick fetuses.
Prenatal withdrawal from opiates interferes with hatching of otherwise viable chick fetuses.
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产前戒断阿片类药物会干扰其他可存活雏鸡胎儿的孵化。
DOI：
10.1126/science.7195069
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Sparber,SB
中科院分区：
文献类型：
--
作者：
Kuwahara,MD;Sparber,SB
Fetal chicks were made opiate-dependent by injections ofN-desmethyl-1-α-acetylmethadol into the chorioallantois on day 3 of embryogenesis. The injections had no effect on subsequent hatchability; however, spontaneous fetal motility was significantly depressed. Injection of naloxone caused a significant increase in the motility of the opiate-exposed fetuses but had no effect on control fetuses. That naloxone's effect was an expression of opiate withdrawal and not due to antagonism of depressed motility is also supported by the observation that naloxone significantly reduced the hatchability of opiate-exposed chicks and not of control chicks. Thus the withdrawal of a developing organism from a narcotic may be more deleterious to its survival than continued exposure.
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影响因子：
9.8
作者：
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通讯作者：
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DOI：
--
发表时间：
1980
期刊：
影响因子：
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作者：
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作者：
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影响因子：
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作者：
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DOI：
10.1126/science.7195068
发表时间：
1981
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Lichtblau,L;Sparber,SB
通讯作者：
Sparber,SB