Inhibition of the proliferation of human neural neoplastic cell lines by cysteamine
Inhibition of the proliferation of human neural neoplastic cell lines by cysteamine
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DOI：
10.1016/0304-3835(96)04200-0
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发表时间：
1996-05-15
期刊：
影响因子：
9.7
通讯作者：
Renton, FJ
中科院分区：
文献类型：
--
作者：
Jeitner, TM;Renton, FJ
Cysteamine (CySH), a thiol compound that crosses the blood-brain barrier, inhibited the proliferation of neural neoplastic cells in vitro. The IC50 Of cysteamine with respect to inhibition after 72 h of drug exposure, was similar to 70 mu M in the glioma cell line, 2607, and similar to 80 mu M in the neuroblastoma cell line, DAOY. Interestingly, the inhibition of proliferation of 2607 cells produced by 72 h treatment with CySH could also be induced with exposure periods as short as 8 h. Another thiol bearing compound, penicillamine methyl ester, also arrested the proliferation of 2607 cells with IC50 similar to 160 mu M. Cell cycle analysis revealed that CySH acted to lengthen the cell cycle period of 2607 cells by slowing the passage of cells through S phase and caused the cells to finally arrest in G(2)/M. In the other cell lines tested, CySH arrested cells in all phases of the cell cycle. These observations suggest that CySH and its congeners may have some utility in the treatment of neoplasia in vivo.
