Characterization of labeled neural progenitor cells for magnetic targeting
Characterization of labeled neural progenitor cells for magnetic targeting
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DOI：
10.1097/01.wnr.0000177006.14108.2a
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发表时间：
2005-10-17
期刊：
影响因子：
1.7
通讯作者：
Ochi, M
中科院分区：
文献类型：
--
作者：
Hamasaki, T;Tanaka, N;Ochi, M
对于中枢神经系统的许多疾病和损伤，神经祖细胞移植正在被评估为一种可能的治疗选择。虽然局部、静脉内和蛛网膜下注射已被报道为神经祖细胞的给药方法，但这些方法中的每一种都有局限性。更有效和微创的细胞输送系统是移植神经祖细胞所必需的。在这项研究中，我们开发了一种技术，形成磁标记的神经祖细胞的磁靶向系统。我们证明了神经前体细胞可以与磁珠偶联，并且标记的神经前体细胞保留了未标记神经前体细胞的特征，并且它们可以在体外通过磁力定位。标记的神经前体细胞具有用于磁靶向系统体内模型的潜力。
For many diseases and injuries of the central nervous system, transplantation of neural progenitor cells is being evaluated as a possible treatment option. Although local, intravenous and subarachnoid injections have been reported as administration methods of neural progenitor cells, each of these methods has limitations. More effective and minimally invasive cell delivery systems are necessary for transplanting neural progenitor cells. In this study, we have developed a technique to form magnetically labeled neural progenitor cells for a magnetic targeting system. We demonstrated that neural progenitor cells can couple with magnetic beads, and that the labeled neural progenitor cells preserve the characteristics of non-labeled neural progenitor cells, and that they can be localized by magnetic force in vitro. Labeled neural progenitor cells have the potential to be used in magnetic targeting systems in-vivo models.