Gait Patterns in Children With Cancer and Vincristine Neuropathy
Gait Patterns in Children With Cancer and Vincristine Neuropathy
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DOI：
10.1097/pep.0000000000000208
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发表时间：
2016-03-01
影响因子：
1.6
通讯作者：
Tanner, Lynn
中科院分区：
文献类型：
--
作者：
Gilchrist, Laura;Tanner, Lynn
Purpose: Children treated with vincristine often develop chemotherapy-induced peripheral neuropathy (CIPN), but effects of CIPN on gait have not been reported. Methods: Gait variables of 52 children/adolescents treated for non-central nervous system cancers with CIPN were compared with an age-and sex-matched control group. Gait data were collected via GaitRite walkway before and after completing a 6-minute walk test (6MWT). Ankle range-of-motion (ROM) measures, balance, and strength tests were also completed. Results: Participants with CIPN had decreased velocity and step length. Ankle ROM and balance explained variability in step length. Both groups increased self-selected velocity after the 6MWT, but participants with cancer walked with slower velocity, shorter step length, and decreased cadence. Strength, neuropathy, and self-selected velocity measured before the 6MWT explained variability in 6MWT scores. Conclusions: Ankle ROM and balance are important factors when treating step length deficits, whereas strength is also an important consideration for walking capacity.
