Partial sequencing of env gene of bovine leukaemia virus from Brazilian samples and phylogenetic analysis
Partial sequencing of env gene of bovine leukaemia virus from Brazilian samples and phylogenetic analysis
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DOI：
10.1046/j.1439-0450.2002.00582.x
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发表时间：
2002-09-01
期刊：
影响因子：
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通讯作者：
Leite, RC
中科院分区：
文献类型：
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作者：
Camargos, MF;Stancek, D;Leite, RC
对从巴西三个不同地区分离的三种 BLV 毒株获得的部分牛白血病病毒 (BLV) env gp51 基因序列进行了分析。将巴西 BLV env gp51 序列与在不同国家分离的 BLV 毒株的其他七个相应序列以及共有序列进行了比较。就单点突变的发生而言，获得的有关分析菌株之间定性和定量差异的数据点。两种巴西菌株的突变率明显高于其他分析菌株。然而，氨基酸分析并未显示 BLV env gp51 基因的高度保守区域编码的初级蛋白质结构发生任何实质性变化。基于获得的数据，还提出了所研究的 BLV 毒株之间可能的系统发育关系的推定树状图图像。
Analysis of the partial bovine leukaemia virus (BLV) env gp51 gene sequences obtained from three BLV strains isolated in three different regions of Brazil was carried out. The Brazilian BLV env gp51 sequences were compared with seven other corresponding sequences of BLV strains isolated in different countries and with consensus sequence as well. The obtained data point on qualitative and quantitative differences among the analysed strains as far as the occurrence of single point mutations is concerned. Two Brazilian strains show significantly higher mutation rate than other analysed strains. Amino acid analysis did not show, however, any substantial changes of the primary protein structure coded by well conserved region of BLV env gp51 gene. Based on the obtained data, the putative dendogram image of possible phylogenetic relations among the studied BLV strains is presented as well.