Multifacility Outbreak of Middle East Respiratory Syndrome in Taif, Saudi Arabia.
Multifacility Outbreak of Middle East Respiratory Syndrome in Taif, Saudi Arabia.
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DOI：
10.3201/eid2201.151370
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发表时间：
2016-01
影响因子：
11.8
通讯作者：
Watson JT
中科院分区：
文献类型：
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作者：
Assiri A;Abedi GR;Bin Saeed AA;Abdalla MA;al-Masry M;Choudhry AJ;Lu X;Erdman DD;Tatti K;Binder AM;Rudd J;Tokars J;Miao C;Alarbash H;Nooh R;Pallansch M;Gerber SI;Watson JT
需要加强监测和感染控制做法，以防止卫生保健环境中的暴发。中东呼吸综合征冠状病毒(MERS-CoV)是2012年首次报道的一种新型呼吸道病原体。2014年9月至2015年1月，沙特阿拉伯塔伊夫的4家医疗机构报告了38例中东呼吸综合征疫情；38名病例患者中有21人死亡。临床和公共卫生记录显示，13名患者为医护人员(HCP)。15例患者，包括4例HCP，与1个透析单元相关。该透析室中另外三个HCP有MERS冠状病毒感染的血清学证据。从15例急性期患者的血清标本中扩增出病毒RNA，从10例患者的血清标本中扩增出完整的棘突基因编码序列，形成一个离散的聚类群；从9例患者的样本中获得了紧密相关的序列。在没有时间或地点联系的患者中，相似的基因序列表明病毒传播未被识别。在很长一段时间内，多种保健环境中的疫情持续存在，这突显了加强MERS冠状病毒监测和感染控制做法的重要性。
Enhanced surveillance and infection-control practices are needed to prevent outbreaks in healthcare settings. Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) is a novel respiratory pathogen first reported in 2012. During September 2014–January 2015, an outbreak of 38 cases of MERS was reported from 4 healthcare facilities in Taif, Saudi Arabia; 21 of the 38 case-patients died. Clinical and public health records showed that 13 patients were healthcare personnel (HCP). Fifteen patients, including 4 HCP, were associated with 1 dialysis unit. Three additional HCP in this dialysis unit had serologic evidence of MERS-CoV infection. Viral RNA was amplified from acute-phase serum specimens of 15 patients, and full spike gene-coding sequencing was obtained from 10 patients who formed a discrete cluster; sequences from specimens of 9 patients were closely related. Similar gene sequences among patients unlinked by time or location suggest unrecognized viral transmission. Circulation persisted in multiple healthcare settings over an extended period, underscoring the importance of strengthening MERS-CoV surveillance and infection-control practices.