STIMULUS-SPECIFIC ADAPTATION AND ITS DYNAMICS IN THE INFERIOR COLLICULUS OF RAT
STIMULUS-SPECIFIC ADAPTATION AND ITS DYNAMICS IN THE INFERIOR COLLICULUS OF RAT
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DOI：
10.1016/j.neuroscience.2011.01.060
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发表时间：
2011-05-05
期刊：
影响因子：
3.3
通讯作者：
Hong, B.
中科院分区：
文献类型：
--
作者：
Zhao, L.;Liu, Y.;Hong, B.
刺激特异性适应（SSA）是指神经元对常见刺激的反应比对罕见刺激的反应降低。以往的研究表明，SSA发生在从下丘（IC）、听丘脑到听皮层（AC）的听觉通路的不同层次。在本研究中，我们进一步研究了SSA在大鼠IC的oddball范式的性质。我们找到了特别探员。除了先前的研究中所示的相对较高的频率（>= 2Hz）之外，甚至在较低的重复频率（1Hz）下也存在。我们还分析了适应整个刺激序列的时间动态。在应对过程中发现了全球和地方两个组成部分。这些组成部分包括在整个oddball序列的长期适应，一个短期增加的反应，常见的刺激后，罕见的和刺激的历史对当前的反应的影响。通过拟合一个关于刺激局部历史和整体概率的线性模型，我们发现它们都影响IC神经元的反应。我们的研究进一步支持了在IC中SSA的存在，并提供了在中脑水平上的新奇检测的神经处理的详细特性。(C)2011年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Stimulus specific adaptation (SSA) is known as a decrease of neuronal response to stimuli that are commonly presented than those rarely occurred. Previous studies have shown that SSA occurs at different levels of auditory pathway, from inferior colliculus (IC), auditory thalamus to auditory cortex (AC). In this study, we further investigated the properties of SSA in rat IC using oddball paradigm. We found that SSA. existed even at a lower repetition rate (1 Hz), besides at relatively higher rates (>= 2 Hz) shown in previous studies. We also analyzed the temporal dynamics of adaptation to the entire stimulus sequence. Global and local components were found in the response process. These components include a long-term adaptation during the entire oddball sequence, a short-term increase of responses to common stimuli after rare ones and the effects of stimulus history on current response. By fitting a linear model regarding stimulus local history and global probability, we found both of them affect IC neuronal responses. Our study further supports the existence of SSA in IC and provides detailed properties of the neural processing of novelty detection at midbrain level. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.