The role of microRNAs in mammalian oocytes and embryos
The role of microRNAs in mammalian oocytes and embryos
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DOI：
10.1016/j.anireprosci.2012.08.009
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发表时间：
2012-09-01
影响因子：
2.2
通讯作者：
Tesfaye, D.
中科院分区：
文献类型：
--
作者：
Hossain, M. M.;Salilew-Wondim, D.;Tesfaye, D.
先进的基因组分析揭示了大量的非编码RNA（ncRNA），它们在转录和转录后水平对不同的细胞过程具有重要的功能。在非编码RNA中，microRNA（miRNAs）通过转录后调节基因表达，在疾病、生育和发育中发挥重要作用，近年来受到广泛关注。miRNA和miRNA加工机制基因在卵母细胞和植入前胚胎中的存在和时空表达证明了miRNA参与哺乳动物卵母细胞的生长和成熟、早期胚胎发育、干细胞谱系分化和植入。因此，本文旨在强调的重要性，miRNAs及其介导的翻译重编程在哺乳动物卵母细胞和胚胎的生理和发育的初步证据。(c)2012爱思唯尔有限公司版权所有。
Advanced genomic analysis has revealed an enormous inventory of non-coding RNAs (ncRNAs), which are functionally important at transcriptional and post-transcriptional level for different cellular processes. Among the ncRNAs, microRNAs (miRNAs) have recently been highlighted extensively for their pivotal role in disease, fertility and development through post-transcriptional regulation of gene expression. The presence and spatio-temporal expression of miRNAs and miRNA processing machinery genes in oocytes and preimplantation embryos has evidenced the involvement of miRNAs for growth and maturation of mammalian oocytes, early embryonic development, stem cell lineage differentiation and implantation. Therefore, this article aims to highlight primary evidences on the importance of miRNAs and their mediated translational reprogramming in the physiology and development of mammalian oocytes and embryos. (c) 2012 Elsevier B.V. All rights reserved.