B Cell Lymphoma
B Cell Lymphoma
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B细胞淋巴瘤
DOI：
10.1007/978-981-15-3532-1_12
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Wang, Ji-Yang
中科院分区：
文献类型：
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作者：
Meng, Xin;Min, Qing;Wang, Ji-Yang
B细胞的发育和活化伴随着动态的遗传改变，包括V（D）J重排和免疫球蛋白基因体细胞超突变和类别转换重组。这些遗传事件的异常可引起染色体易位和基因组突变，导致参与B细胞存活或增殖的基因的表达和功能改变，从而导致B淋巴瘤发生。事实上，B细胞淋巴瘤占淋巴瘤的95%。在本章中，我们总结了最常见的B细胞淋巴瘤类型的形态学、免疫表型、临床特征、导致恶性肿瘤的遗传缺陷、治疗和预后，包括典型的前体B细胞恶性淋巴瘤（B-ALL/LBL）和成熟B细胞淋巴瘤（霍奇金淋巴瘤和B细胞非霍奇金淋巴瘤）。
B cell development and activation are accompanied by dynamic genetic alterations including V (D)J rearrangements and immunoglobulin-gene somatic hypermutation and class-switch recombination. Abnormalities in these genetic events can cause chromosomal translocations and genomic mutations, leading to altered expression and function of genes involved in B cell survival or proliferation and consequently B lymphoma-genesis. In fact, B cell lymphoma accounts for 95% of the lymphomas. In this chapter, we summarize the morphology, immunophenotypes, clinical features, genetic defects that cause the malignancies, treatments, and prognosis of the most prevalent types of B cell lymphomas, including typical precursor B cell malignance (B-ALL/LBL) and mature B cell lymphoma (Hodgkin lymphoma and B cell non-Hodgkin lymphoma).