From Atoxyl to Salvarsan: Searching for the Magic Bullet
From Atoxyl to Salvarsan: Searching for the Magic Bullet
复制标题
从 Atoxyl 到 Salvarsan：寻找灵丹妙药
作者：
S. Riethmiller
2004年3月15日是保罗·埃尔利希诞辰150周年纪念日。他是现代化疗的创始人，事实上，他创造了这个词，并发明了化学疗法这门科学。他和他的化学家Al Fred Bertheim是做三件事的第一人：(1)鉴定一种物质，无论是人造的还是从天然产品中，显示出杀死某些入侵生物的希望；(2)确定这种物质中活性化合物的正确结构；以及(3)修改这种化合物的化学结构，使其对入侵生物更有效，对宿主的伤害更小。
March 15th of 2004 marked the 150th anniversary of the birth of Paul Ehrlich. He was the founder of modern chemotherapy and in fact coined the word and invented the science of chemical therapy. He and his chemist Al fred Bertheim were the first people to do three things: (1) identify a substance, either man-made or from natural products, which showed promise in killing certain invading organisms; (2) determine the correct structure of the active compound in this substance, and (3) modify the chemical structure of this compound to make it more potent to invading organisms and less harmful to the host.