False-positive 2-[F-18]-fluoro-2-deoxy-D-glucose positron emission tomography studies for evaluation of focal pulmonary abnormalities.
False-positive 2-[F-18]-fluoro-2-deoxy-D-glucose positron emission tomography studies for evaluation of focal pulmonary abnormalities.
复制标题
用于评估局灶性肺部异常的假阳性 2-[F-18]-氟-2-脱氧-D-葡萄糖正电子发射断层扫描研究。
DOI：
10.1007/bf03165391
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
C. Su
中科院分区：
文献类型：
--
作者：
R. Yen;M. L. Chen;F. Y. Liu;S. Ko;Y. L. Chang;P. Chieng;C. Su
2-[F-18]-氟-2-脱氧-D-葡萄糖(FDG)正电子发射断层扫描(PET)可以显示病变的糖代谢特征，有助于肺部局灶性病变的良、恶性鉴别。恶性细胞表现出比良性病变更高的葡萄糖代谢活性。然而，一些炎症过程也显示出显著的FDG摄取。我们提出两个病例，在肺部的炎性病变中发现高摄取FDG。第一例是一名38岁妇女，患有慢性咳嗽20多年。FDG正电子发射计算机断层扫描显示右中肺后方有一高代谢病变，病变与背景的比率为8.0。她接受了开胸手术和肿瘤切除，并被诊断出患有隐球菌病。第二例为72岁女性，曾患肺结核病，左下叶有空洞。她在入院前几天一直有发烧、发冷和大咯血的症状。FDGPET显示空洞周围有一高代谢环。病灶与背景的比值为7.8。回声引导下的活组织检查显示没有恶性肿瘤的证据。她接受了抗生素治疗，症状逐渐消退。诊断为肺脓肿合并先前存在的空洞。这两个病例证实，FDG PET阳性结果在鉴别肺部良性和恶性异常时应谨慎解释，特别是在肉芽肿性病变高发的地区。
Positron emission tomography (PET) with 2-[F-18]-fluoro-2-deoxy-D-glucose (FDG) can demonstrate the glucose metabolism characteristics of a lesion, which may be helpful in differentiating between benign and malignant focal pulmonary lesions. Malignant cells demonstrate higher glucose metabolic activity than benign lesions. However, some inflammatory processes also show significant FDG uptake. We present two cases where high FDG uptake was found in inflammatory lesions in the lungs. The first case was that of a 38-year-old woman with chronic cough for more than 20 years. FDG PET revealed a hypermetabolic lesion with a lesion-to-background ratio of 8.0 at the posterior aspect of the right middle lung. She underwent thoracotomy and tumor resection, and was diagnosed with cryptococcosis. The second case was that of a 72-year-old woman who had pulmonary tuberculosis previously with cavitation in the left lower lobe. She suffered from fever, chills and severe hemoptysis for several days before this admission. FDG PET revealed a hypermetabolic ring at the periphery of the cavity. The lesion-to-background ratio was 7.8. Echo-guided biopsy showed no evidence of malignancy. She was treated with antibiotics and the symptoms subsided gradually. Lung abscess complicating a pre-existing cavity was diagnosed. These two cases substantiate that positive FDG PET results should be interpreted with caution in differentiating benign from malignant pulmonary abnormalities, especially in regions with a high prevalence of granulomatous lesions.