CORTICOTROPIN-RELEASING HORMONE INHIBITION OF GONADOTROPIN-SECRETION DURING THE MENSTRUAL-CYCLE
CORTICOTROPIN-RELEASING HORMONE INHIBITION OF GONADOTROPIN-SECRETION DURING THE MENSTRUAL-CYCLE
复制标题
DOI：
10.1016/0026-0495(89)90208-4
复制
发表时间：
1989-06-01
影响因子：
9.8
通讯作者：
BARINI, A
中科院分区：
文献类型：
--
作者：
BARBARINO, A;DEMARINIS, L;BARINI, A
为了确定促肾上腺皮质激素释放激素（CRH）是否对正常生育妇女的促性腺激素分泌产生抑制作用，研究了CRH对月经周期中促黄体生成激素（LH）、促卵泡激素（FSH）和皮质醇分泌的影响。CRH在周期的卵泡中期对LH的释放没有影响。相比之下，静脉注射100 μ g CRH在周期的卵泡晚期（~ 50%）和黄体中期（~ 52%）引起LH浓度的显著降低。LH浓度在注射CRH后4小时内下降，并在注射后5小时恢复到对照期间观察到的水平。同样地，CRH在周期的黄体中期引起FSH分泌的显著减少。CRH注射增加皮质醇释放在所有阶段的周期.这些数据表明，外源性CRH管理的结果在卵泡后期和黄体中期的周期中的促性腺激素分泌的抑制。这些结果表明，内源性CRH水平升高，导致皮质醇分泌增加，可能有助于减少促性腺激素分泌，因此，在妇女的压力条件下，生殖功能的中断。
To determine whether corticotropin-releasing hormone (CRH) exerts an inhibitory action on gonadotropin secretion in normal fertile women, the effects of CRH on luteinizing hormone (LH), follicle-stimulating hormone (FSH), and cortisol secretion were studied during the menstrual cycle. CRH had no effect on LH release during the midfollicular phase of the cycle. By contrast, IV injection of 100 .mu.g CRH elicited significant decreases in LH concentrations during late follicular (-50%) and midluteal (-52%) phases of the cycle. LH concentrations decreased during the four-hours following injection of CRH and returned to those observed during the control period five hours after injection. Similarly, CRH elicited a signifcantly decrease in FSH secretion during the midluteal phase of the cycle. CRH injection an increase in cortisol release during all phases of the cycle. These data demonstrate that exogenous CRH administration results in inhibition of gonadotropin secretion in late follicular and midluteal phases of the cycle. These results suggest that elevated endogenous CRH levels resulting in increased cortisol secretion could contribute to decreased gonadotropin secretion and, thus, disruption of reproductive function during stressful conditions in women.