Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy
Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy
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DOI：
10.1002/adhm.201600550
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发表时间：
2017-01-01
影响因子：
10
通讯作者：
Aime, Silvio
中科院分区：
文献类型：
--
作者：
Longo, Dario L.;Stefania, Rachele;Aime, Silvio
描述了一种用于肿瘤光声成像的动态对比增强(DCE)方法。合成了新型水溶性黑色素衍生物，具有良好的PA性能、稳定性、安全性和在荷瘤小鼠体内的蓄积作用。这种黑色素衍生物能够表征肿瘤血管，并监测抗血管生成治疗后血管通透性的变化。DCE-PA成像可以评估癌症治疗的功能反应。
A dynamic contrast enhanced (DCE) approach for tumor photoacoustic (PA) imaging is described. Novel water soluble melanin-based derivatives are synthesized that exhibit good PA properties, stability, safety and accumulation in tumor bearing mice. This melanin derivative is capable to characterize tumor vasculature and to monitor vessel permeability changes upon antiangiogenic treatment. DCE-PA imaging can assess functional response to cancer treatments.