Influence of arteriolar hyalinization on arterial intimal fibroplasia in the renal cortex of subjects in the United States, Peru, and Bolivia, applicable also to other populations.
Influence of arteriolar hyalinization on arterial intimal fibroplasia in the renal cortex of subjects in the United States, Peru, and Bolivia, applicable also to other populations.
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DOI：
10.1016/s0895-7061(02)03084-4
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发表时间：
2002-12
影响因子：
3.2
通讯作者：
R. Tracy;D. Parra;Wilber Eisaguirre;R. A. Torres Balanza
中科院分区：
文献类型：
--
作者：
R. Tracy;D. Parra;Wilber Eisaguirre;R. A. Torres Balanza
Microvasculopathies of nephrosclerosis progress with age in contrasting patterns. Arterial intimal fibroplasia (Rrand Rc, respectively, in small and large interlobular arteries) previously showed close linkages to hypertension and to “nephrosclerosis,” defined by fibrous replacement of atrophied nephrons, whereas hyalinization of arterioles (Hy) failed to show consistent linkages. In this study, renal samples from seven populations, three newly assembled and four reassessed from archived data, were evaluated for Rr, Rc, and Hy in forensic autopsies ofbasalsubjects (ie, those lacking conditions known to correlate with hypertension or nephrosclerosis, mostly deaths by violence). The patterns of progression on age were alike in all populations, but the rates of progression differed greatly. The observed ranges indicate a 547% higher rate for Hy in the fastest compared with the slowest population, a 49% higher rate for Rc, and a 107% higher rate for Rr. About one third of variation in Rrand Rcbetween populations can be attributed to the correlation with Hy, leaving a substantial residual effect independent of Hy. The findings suggest that the etiology propelling hyalinization in arterioles seems somehow to accelerate the progression of intimal fibroplasia in arteries. The reverse direction, fibroplasia somehow accelerating hyalinization, seems unreasonable, because the presumed consequence, Hy, fails to increase notably with age after 40 years, whereas the presumed causes, Rrand Rc, rise unremittingly into old age. The etiologies of the population differences are of great consequence to public health but remain unknown. Am J Hypertens 2002;15:1064–1073 © 2002 American Journal of Hypertension, Ltd.
