Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives.
Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives.
复制标题
DOI：
10.1016/s0960-894x(99)00375-3
复制
发表时间：
1999-08
影响因子：
2.7
通讯作者：
W. C. Xu;Q. Zhou;C. Ashendel;C. Chang;C. Chang
中科院分区：
文献类型：
--
作者：
W. C. Xu;Q. Zhou;C. Ashendel;C. Chang;C. Chang
A series of β-substituted polythiophene derivatives was synthesized through palladium-catalyzed coupling reaction. Their structure-protein kinase C (PKC) inhibitory activity relationship was studied. The carboxaldehyde and hydroxymethyl derivatives of α-terthiophene were potent PKC inhibitors (IC50= 10−7M).
