Hippocampal regulation of contextual cue-induced reinstatement of cocaine-seeking behavior
Hippocampal regulation of contextual cue-induced reinstatement of cocaine-seeking behavior
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DOI：
10.1016/j.pbb.2008.04.007
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发表时间：
2008-09-01
影响因子：
3.6
通讯作者：
Kantak, Kathleen M.
中科院分区：
文献类型：
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作者：
Atkins, Alison L.;Mashhoon, Yasmin;Kantak, Kathleen M.
可卡因和线索之间的联系促进了成瘾的发展和维持。我们假设腹侧海马对这些关联的获得很重要。大鼠进行训练，自我管理可卡因，或没有预先暴露于不同的可卡因和盐水配对的上下文线索。接下来，大鼠用不同的上下文线索组与可卡因和盐水沿着与不同的离散线索配对进行条件反射3天。在预处理之前，将溶剂或利多卡因注入腹侧海马。灭绝后，恢复可卡因寻求行为进行了检查后，暴露于上下文线索，离散线索，或其组合。在条件反射过程中，腹侧海马的失活阻断了可卡因和可卡因配对的上下文线索之间的关联的获取，只有利多卡因治疗的大鼠与短期的线索暴露未能恢复可卡因配对的上下文线索的存在下的反应。利多卡因也阻止了两个线索暴露组的大鼠在恢复测试期间区分可卡因和盐水配对的上下文线索。可卡因配对的离散线索或上下文和离散线索一起诱导的恢复没有受损的线索暴露条件。海马是重要的收购可卡因和上下文之间的关联，并保持可卡因相关和不相关的上下文线索之间的歧视。(C)2008年爱思唯尔公司All rights reserved.
Associations between cocaine and cues facilitate development and maintenance of addiction. We hypothesized that the ventral hippocampus is important for acquisition of these associations. Rats were trained to self-administer cocaine, with or without pre-exposure to distinct sets of cocaine- and saline-paired contextual cues. Next, rats were conditioned for 3 days with the distinct sets of contextual cues paired with cocaine and saline along with distinct discrete cues. Vehicle or lidocaine was infused into the ventral hippocampus prior to conditioning sessions. Following extinction, reinstatement of cocaine-seeking behavior was examined following exposure to contextual cues, discrete cues, or their combination. Inactivation of the ventral hippocampus during conditioning blocked acquisition of the association between cocaine and cocaine-paired contextual cues in that only lidocaine-treated rats with short-term cue exposure failed to reinstate responding in the presence of cocaine-paired contextual cues. Lidocaine also prevented rats in both cue exposure groups from discriminating between cocaine- and saline-paired contextual cues during reinstatement tests. Reinstatement induced by cocaine-paired discrete cues or by contextual and discrete cues together was not impaired for either cue exposure condition. The hippocampus is important for acquisition of the association between cocaine and context and in maintaining discrimination between cocaine-relevant and -irrelevant contextual cues. (C) 2008 Elsevier Inc. All rights reserved.