Creatine kinase BB in brain in schizophrenia
Creatine kinase BB in brain in schizophrenia
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DOI：
10.1080/15622970310029916
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发表时间：
2003-10-01
影响因子：
3.1
通讯作者：
Boksha, IS
中科院分区：
文献类型：
--
作者：
Burbaeva, GS;Savushkina, OK;Boksha, IS
肌酸激酶（CK）负责肌酸/磷酸肌酸水平，已知其在精神分裂症患者的大脑中改变。比较估计CK酶活性和CK BB的免疫反应性进行了易溶提取物额叶皮质，前，后扣带皮质，海马和小脑与精神分裂症患者与正常对照组的大脑。CK活性用商品化试剂盒测定。采用单克隆抗体ECL免疫印迹法评价CK BB免疫反应性。与对照组相比，精神分裂症患者的所有脑区CK活性和CK-BB免疫反应性均显著下降（p
Creatine kinase (CK) is responsible for the creatine/ creatine phosphate level, which is known to alter in tire brain of patients with schizophrenia. A comparative estimation of CK enzymatic activity and immunoreactivity of CK BB was carried out in readily soluble extracts from frontal cortex, anterior and posterior cingulate cortex, hippocampus and cerebellum from brains of individuals with schizophrenia versus normal controls. CK activity was determined rising a commercial diagnostic kit. CK BB immunoreactivity was evaluated by ECL-immunoblotting using monoclonal antibody. A drastic drop of CK activity and CK BB immunoreactivity was observed in all the examined brain areas in schizophrenic patients compared to controls (p