Schizophrenics show spatial working memory deficits.
Schizophrenics show spatial working memory deficits.
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DOI：
10.1001/archpsyc.1992.01820120063009
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发表时间：
1992-12
影响因子：
--
通讯作者：
Sohee Park;P. Holzman
中科院分区：
文献类型：
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作者：
Sohee Park;P. Holzman
本研究表明，精神分裂症患者在空间延迟反应任务中受到损害，类似于用于评估恒河猴背外侧前额叶皮质工作记忆功能的任务。精神分裂症患者和两个对照组，正常受试者和双相情感障碍患者，进行了测试的视觉版本的记忆任务，触觉版本的相同的任务，和两个控制任务：感觉任务，不需要工作记忆和数字广度测试。精神分裂症患者表现出显着的赤字相对于两个对照组在视觉和触觉延迟反应任务。然而，他们在数字广度测试中没有受损，该测试利用了语言工作记忆和自愿注意力，在感觉控制任务中，他们的反应受到外部线索而不是空间工作记忆的指导。这些研究结果提供了直接的证据，精神分裂症患者遭受损失的表征处理，这种赤字是独立的方式。这些空间工作记忆的数据增加了越来越多的证据，参与背外侧前额叶皮层在精神分裂症的疾病。
The present study demonstrates that schizophrenics are impaired on spatial delayed-response tasks, analogous to those that have been used to assess the working memory function of the dorsolateral prefrontal cortex in rhesus monkeys. Schizophrenic patients and two control groups, normal subjects and bipolar psychiatric patients, were tested on the oculomotor version of the memory task, a haptic version of the same task, and two control tasks: a sensory task that did not require working memory and a digit span test. The schizophrenic patients showed marked deficits relative to the two control groups in both the oculomotor and haptic delayed-response tasks. They were not, however, impaired on the digit span test, which taps verbal working memory as well as voluntary attention, and on the sensory control task, in which their responses were guided by external cues rather than by spatial working memory. These findings provide direct evidence that schizophrenics suffer a loss in representational processing and that this deficit is modality independent. These data on spatial working memory add to the growing evidence for involvement of the dorsolateral prefrontal cortex in schizophrenic disease.