Selenium-Doped Carbon Quantum Dots for Free-Radical Scavenging
Selenium-Doped Carbon Quantum Dots for Free-Radical Scavenging
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DOI：
10.1002/anie.201705989
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发表时间：
2017-08-07
影响因子：
16.6
通讯作者：
Xu, Huaping
中科院分区：
文献类型：
--
作者：
Li, Feng;Li, Tianyu;Xu, Huaping
杂原子掺杂是调节碳量子点荧光特性的有效途径。然而，尽管硒由于其特殊的电负性而具有独特的化学性质，如氧化还原反应性质，但硒掺杂碳点的报道却很少。本文在温和条件下，通过水热处理硒半胱氨酸，制备了具有绿色荧光（量子产率为7.6%）的硒掺杂碳量子点（Se-CQDs）。硒杂原子使硒- cqds具有氧化还原依赖的可逆荧光。此外，Se-CQDs可以有效地清除自由基，如COH。一旦Se-CQDs被内化到细胞中，细胞中有害的高水平活性氧（ROS）就会减少。这一特性使得Se-CQDs能够保护生物系统免受氧化应激的影响。
Heteroatom doping is an effective way to adjust the fluorescent properties of carbon quantum dots. However, selenium-doped carbon dots have rarely been reported, even though selenium has unique chemical properties such as redox-responsive properties owing to its special electronegativity. Herein, a facile and high-output strategy to fabricate selenium-doped carbon quantum dots (Se-CQDs) with green fluorescence (quantum yield 7.6%) is developed through the hydrothermal treatment of selenocystine under mild conditions. Selenium heteroatoms endow the Se-CQDs with redox-dependent reversible fluorescence. Furthermore, free radicals such as COH can be effectively scavenged by the Se-CQDs. Once Se-CQDs are internalized into cells, harmful high levels of reactive oxygen species (ROS) in the cells are decreased. This property makes the Se-CQDs capable of protecting biosystems from oxidative stress.