Comparison of arterial blood pressure in different strains of mice
Comparison of arterial blood pressure in different strains of mice
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DOI：
10.1016/s0895-7061(00)01285-1
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发表时间：
2001-05-01
影响因子：
3.2
通讯作者：
Mattson, DL
中科院分区：
文献类型：
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作者：
Mattson, DL
本研究旨在比较远交Swiss韦伯斯特（SW）和近交系C57 BL/6 J、A/J、C3 HeB/FeJ和SWR/J小鼠24 h/天监测时的静息动脉血压水平。平均动脉压（MAP）和心率（HR）全天变化，在黑暗时间观察到最大值。清醒SW小鼠（N = 6）的收缩压（SAP）、MAP和舒张压（DAP）动脉血压平均值分别为122 +/- 2、112 +/- 2和102 +/- 2 mm Hg。在维持正常钠饮食的SW、C57 BL/6 J（N = 7）、A/J（N = 5）、C3 HeB/FeJ（N = 5）或SWR/J（N = 7）小鼠之间的24小时平均MAP中未检测到差异。平均每日心率（HR）在C3 HeB/FeJ中最高（665 +/- 15次/分钟），在C57 BL/6 J中最低（594 +/- 9次/分钟）。MAP在施用L-NAME的SW小鼠中显著增加（133 +/-2 mm Hg，N = 5），并且在施用卡托普利的SW小鼠中显著降低（99 +/-2 mm Hg，N = 5）。这些研究表明在基线条件下不同小鼠品系中的静息动脉压水平相似。(C)2001年美国高血压杂志有限公司
The present study was performed to compare the resting level of arterial blood pressure when monitored for 24 h/day in outbred Swiss Webster (SW) and inbred C57BL/6J, A/J, C3HeB/FeJ, and SWR/J mice. Mean arterial pressure (MAP) and heart rate (HR) varied throughout the day, with maximal Values observed in the hours of darkness. Systolic (SAP), MAP, and diastolic (DAP) arterial blood pressure averaged 122 +/- 2, 112 +/- 2, and 102 +/- 2 mm Hg, respectively, in conscious SW mice (N = 6). No differences were detected in the 24-h averages of MAP between SW, C57BL/6J (N = 7), A/J (N = 5), C3HeB/FeJ (N = 5), or SWR/J (N = 7) mice maintained on a normal sodium diet. Average daily heart rate (HR) was highest in the C3HeB/FeJ (665 +/- 15 beats/min) and lowest in the C57BL/6J (594 +/- 9 beats/min). The MAP was significantly increased in SW mice administered L-NAME (133 +/- 2 mm Hg, N = 5) and significantly decreased in SW mice administered captopril (99 +/- 2 mm Hg, N = 5), These studies demonstrate similar levels of resting arterial pressure in different mouse strains under baseline conditions. (C) 2001 American Journal of Hypertension, Ltd.