The Nuclear Pore Complex as a Transcription Regulator.
The Nuclear Pore Complex as a Transcription Regulator.
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DOI：
10.1101/cshperspect.a039438
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发表时间：
2021-06
影响因子：
7.2
通讯作者：
M. Sumner;Jason H. Brickner
中科院分区：
文献类型：
--
作者：
M. Sumner;Jason H. Brickner
核孔复合体（NPC）是核膜中高度保守的通道，介导mRNA输出到胞质溶胶和双向蛋白质运输。许多染色体基因座与核孔蛋白（Nups）物理相互作用，与Nups的相互作用可以促进转录抑制，转录激活和转录平衡。与NPC的相互作用也影响基因的空间排列、染色体间聚类和拓扑相关结构域的折叠。因此，NPC是基因组的空间组织者和基因组功能的调节者。
The nuclear pore complex (NPC) is a highly conserved channel in the nuclear envelope that mediates mRNA export to the cytosol and bidirectional protein transport. Many chromosomal loci physically interact with nuclear pore proteins (Nups), and interactions with Nups can promote transcriptional repression, transcriptional activation, and transcriptional poising. Interaction with the NPC also affects the spatial arrangement of genes, interchromosomal clustering, and folding of topologically associated domains. Thus, the NPC is a spatial organizer of the genome and regulator of genome function.