Expression of interstitial collagenase (matrix metalloproteinase-1) in gastric cancers
Expression of interstitial collagenase (matrix metalloproteinase-1) in gastric cancers
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DOI：
10.1111/j.1349-7006.1997.tb00396.x
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发表时间：
1997-04-01
期刊：
影响因子：
--
通讯作者：
Kitajima, M
中科院分区：
文献类型：
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作者：
Sakurai, Y;Otani, Y;Kitajima, M
采用原位杂交和免疫组织化学方法检测基质金属蛋白酶-1(MMP1)基因在胃癌组织中的表达及其蛋白表达情况。间质胶原酶(MMP1)基因在肿瘤腺体间质中有表达，嗜酸性粒细胞的浸润与MMP1基因表达的区域有关。嗜酸性粒细胞浸润程度与基质金属蛋白酶-1mRNA表达水平呈正相关。免疫组织化学染色显示，基质细胞和肿瘤腺体中均有基质金属蛋白酶-1蛋白表达。提示基质细胞在基质细胞的表达中可能起重要作用，提示基质细胞在胃癌的侵袭和转移过程中起着重要的病理生理作用。
The expression of matrix metalloproteinase-1 (MMP-1) gene and the presence of MMP-1 protein in gastric cancer were examined by in situ hybridization and immunohistochemistry. Expression of the interstitial collagenase (MMP-1) gene was detected within the stroma of the neoplastic glands, and infiltration of eosinophils was observed to be associated with regions of MMP-1 gene expression. The degree of eosinophilic infiltration correlated with the level of MMP-1 mRNA expression. Immunostaining showed localization of MMP-1 protein in the stromal cells, and additionally in the neoplastic glands. These findings indicate that the stromal cells may play an important role in the expression of MMP-1, and suggest a pathophysiological role for MMP-1 in the invasion and metastasis of gastric cancer.