Multi-center study on the prevalence of hypothyroidism in patients with hypercholesterolemia
Multi-center study on the prevalence of hypothyroidism in patients with hypercholesterolemia
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DOI：
10.1507/endocrj.k11e-012
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发表时间：
2011-06-01
影响因子：
2
通讯作者：
Naruse, Mitsuhide
中科院分区：
文献类型：
--
作者：
Tagami, Tetsuya;Kimura, Hironori;Naruse, Mitsuhide
高胆固醇血症是常见病中最具代表性的疾病之一。为了评估成人高胆固醇血症人群中甲状腺功能减退症的患病率，我们前瞻性地检查了未经治疗或治疗的高胆固醇血症患者的甲状腺功能，作为一项多中心调查。受试者为接受某些降血脂药物治疗的患者或未接受治疗的总胆固醇（TC）超过220 mg/dL和/或LDL-胆固醇（LDL-C）超过140 mg/dL的患者。在招募的737例患者中，725例（男性300例，女性425例）参与了包括甲状腺功能检查在内的调查。患者的背景包括高血压（51%）、糖尿病（49%）、脂肪肝（17%）、吸烟（15%）和习惯性饮酒（10%）。72%的患者接受了降血脂药物治疗，TC、LDL-C、甘油三酯（TG）、HDL-C和LDL-C/HDL-C比值的平均值分别为204.5 mg/dL、119.6 mg/dL、144.4 mg/dL、60.7 mg/dL和2.25。原发性甲减27例（3.7%）（男11例，女16例），亚临床甲减17例（2.4%），显性甲减10例（1.4%）。中枢性甲状腺功能减退4例（0.6%）。高胆固醇血症患者中甲状腺功能减退的患病率为4.3%。考虑到血脂异常患者数量众多，以及避免不必要给药和相关不良反应的重要性，可能需要对血脂异常患者进行甲状腺功能评价，但成本效益问题有待进一步研究。
Hypercholesterolemia is one of the most representative disorders of the common diseases. To evaluate the prevalence of hypothyroidism in the population of adult hypercholesterolemia, we prospectively examined the thyroid function in patients with untreated or treated hypercholesterolemia as a multi-center survey. Subjects were the patients who were treated with some antilipemic agents or the untreated patients whose total cholesterol (TC) was over 220 mg/dL and/or LDL-cholesterol (LDL-C) over 140 mg/dL. Among 737 cases recruited, 725 cases (300 males and 425 females) participated in the survey including the thyroid function test. The patient's backgrounds include hypertension (51%), diabetes mellitus (49%), fatty liver (17%), smoking (15%), and habitual drinking (10%). The 72% of the patients were treated with some antilipemic agents and the mean values of TC, LDL-C, triglyceride (TG), HDL-cholesterol (HDL-C), and LDL-C/HDL-C ratio were 204.5 mg/dL, 119.6 mg/dL, 144.4 ing/dL, 60.7 mg/dL and 2.25, respectively. The primary hypothyroidism was seen in 27 cases (3.7%) (11 males, 16 females) with subclinical hypothyroidism in 17 cases (2.4%) and overt hypothyroidism in 10 cases (1.4%). The central hypothyroidism was seen in 4 cases (0.6%). The prevalence of hypothyroidism was 4.3% in patients with hypercholesterolemia. Taking account of the large number of patients with dyslipidemia and importance of avoiding unnecessary administration and associated adverse effects, evaluation of the thyroid function could be warranted in patients with dyslipidemia although cost-benefit issues waits further investigation.