A clinical and histopathologic comparison of cardiac sarcoidosis and idiopathic giant cell myocarditis
A clinical and histopathologic comparison of cardiac sarcoidosis and idiopathic giant cell myocarditis
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DOI：
10.1016/s0735-1097(02)02715-8
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发表时间：
2003-01-15
影响因子：
24
通讯作者：
Cooper, LT
中科院分区：
文献类型：
--
作者：
Okura, Y;Dec, GW;Cooper, LT
目的本研究的目的是确定心脏结节病（CS）和特发性巨细胞心肌炎（IGCM）的临床表现和组织学资料的预后价值。背景非缺血性心肌病患者的预后部分取决于组织学诊断。IGCM的存活率很低。预后的组织学相关的实体，心脏结节病（CS），是不太好的建立，和CS和IGCM之间的区别对endomyotrophic活检（EMB）的预后价值是unknown.Methods我们确定了115例患者从多中心IGCM注册CS（n=42）和IGCM（n=73）。我们使用考克斯比例风险模型比较了这两组的临床数据，以评估组织学诊断与生存率之间的关系。为了确定组织学特征是否能可靠地区分这两种实体，两位心脏病理学家对炎症浸润成分进行了半定量分级，并比较了两组之间的结果。
Objectives The goal of this study was to determine the prognostic value of clinical data available at presentation and histology in cardiac sarcoidosis (CS) and idiopathic giant cell myocarditis (IGCM).Background The prognosis of patients with nonischemic cardiomyopathy is partly dependent on the histologic diagnosis. Survival in IGCM is poor. The prognosis of a histologically related entity, cardiac sarcoidosis (CS), is less well established, and the prognostic value of the distinction between CS and IGCM on endomyocardial biopsy (EMB) is unknown.Methods We identified 115 patients from the Multicenter IGCM Registry with CS (n=42) and IGCM (n=73). We compared the clinical data for these two groups using Cox proportional-hazards models to assess the association between histologic diagnosis and survival. In order to determine whether histologic features could reliably diffierentiate these two entities, two cardiac pathologists semiquantitatively graded the inflammatory infiltrate components and compared the results between groups.Results Black race was more frequent in the CS group (31% vs. 4%, p