Serum Interleukin-15 is a Marker of Alopecia Areata Severity.
Serum Interleukin-15 is a Marker of Alopecia Areata Severity.
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DOI：
10.4103/ijt.ijt_80_18
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发表时间：
2019-01-01
影响因子：
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通讯作者：
Younis, Esraa Taha
中科院分区：
文献类型：
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作者：
Ebrahim, Adel Ali;Salem, Rehab Mohammed;Younis, Esraa Taha
背景：白细胞介素-15 (IL-15) 是一种细胞因子，与许多炎症和自身免疫性疾病有关。虽然斑秃 (AA) 是一种自身免疫性疾病，但 AA 患者的血清 IL-15 水平尚未得到很好的研究。 工作目的：我们的目的是评估活动性 AA 中的 IL-15 血清水平。 主题和方法：这项病例对照研究包括 40 名 AA 患者和 40 名表面健康的匹配对照。所有参与者均获得了书面知情同意书。检查头皮以评估脱发斑块的部位、数量和大小，并使用脱发严重程度工具评分（SALT 评分）评估 AA 损伤的严重程度，该评分确定头皮中脱发的百分比。仔细检查身体，以检测任何毛发区域是否有脱发斑块。进行指甲检查以检测是否有指甲受累。采用ELISA试剂盒测定血清IL-15水平。结果：患者血清IL-15水平显着高于对照组（P < 0.001）。全秃患者的血清水平显着高于一、两斑患者，头皮和身体同时受累的患者血清水平显着高于头皮或身体均受累的患者。 SALT评分与血清IL-15水平呈显着正相关（P<0.001）。结论：血清IL-15可能是AA严重程度的标志物。
BACKGROUND: Interleukin-15 (IL-15) is a cytokine that is involved in many inflammatory and autoimmune diseases. Although alopecia areata (AA) is an autoimmune disease, serum levels of IL-15 have not been studied well in AA patients.AIM OF THE WORK: We aims at evaluating the serum levels of IL-15 in active AA.SUBJECT AND METHODS: This case-control study included 40 AA patients and 40 apparently healthy matched controls. Written informed consents were obtained from all the participants. The scalp was examined to assess sites, number, and size of alopecia patches, and the severity of AA lesions was assessed using the Severity of Alopecia Tool score (SALT score) which determine the percentage of hair loss in the scalp. The body was carefully examined to detect any alopecia patches in any hairy area. Nail examination was carried out to detect any nail involvement. Serum IL-15 levels were measured using an ELISA kits.RESULTS: Serum levels of IL-15 in patients were significantly higher than those in the control group (P < 0.001). Serum levels in alopecia totalis were significantly higher than those with one or two patches, and serum levels in patients with both scalp and body involvement were significantly elevated than the levels of patients with either scalp or body involvement. There was a statistically significant positive correlation between SALT score and serum levels of IL-15 (P < 0.001).CONCLUSION: Serum IL-15 may be a marker of AA severity.