Perspective: functional genomics towards new biotechnology in medicinal plants
Perspective: functional genomics towards new biotechnology in medicinal plants
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DOI：
10.1007/s11816-018-0476-9
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发表时间：
2018-02
影响因子：
2.4
通讯作者：
M. Yamazaki;Amit Rai;N. Yoshimoto;K. Saito
中科院分区：
文献类型：
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作者：
M. Yamazaki;Amit Rai;N. Yoshimoto;K. Saito
功能基因组学的研究将以前所未有的速度揭示药用植物中特殊代谢产物的化学多样性和功能的秘密。这主要归功于高通量DNA测序以及代谢组学等其他组学技术的显著进步，特别是由于获取，存储和分析大量组学数据集的成本大幅降低。一旦植物中特定化合物的生物合成途径中涉及的基因被阐明，合成生物学或基因组编辑可以应用于在工程生物体中产生目标化合物或操纵植物中的途径。再加上这些进展的途径阐明的方法，现代植物生物技术战略必将大大有助于联合国制定的可持续发展目标。
The secret of chemical diversity and function of specialized metabolites in medicinal plants will be unveiled by study of functional genomics at an unprecedentedly rapid rate in the coming years. This is mostly ascribed to the remarkable advancement in the high-throughput DNA sequencing together with other omics technologies such as metabolomics, in particular, due to drastic reduction in the cost of acquiring, storing and analyzing massive omics datasets. Once the genes involved in a biosynthetic pathway of specialized compounds in plants are elucidated, synthetic biology or genome editing can be applied to produce the target compounds in an engineered organism or to manipulate the pathway in planta. Coupled with these advancements in pathway elucidation approaches, modern plant biotechnology strategies are bound to significantly contribute to the sustainable development goals set by United Nations.