Water-soluble chitosan and herbal honey compound alleviates atopic dermatitis-like lesions in NC/Nga mice
Water-soluble chitosan and herbal honey compound alleviates atopic dermatitis-like lesions in NC/Nga mice
复制标题
水溶性壳聚糖和草药蜂蜜复合物可减轻 NC/Nga 小鼠的特应性皮炎样病变
DOI：
10.1016/j.jiec.2013.05.008
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发表时间：
2014
影响因子：
6.1
通讯作者：
J. Nah
中科院分区：
文献类型：
--
作者：
Changyong Choi;Won;Yung;Seong;Mi;J. Nah
特应性皮炎 (AD) 是一种慢性炎症性皮肤病，受到遗传、环境、免疫和生化因素复杂相互作用的影响，但 AD 的病因仍不清楚。其特点是血清免疫球蛋白 E (IgE) 水平升高、免疫异常以及组织和外周血中嗜酸性粒细胞增多。在本研究中，我们应用含有低分子量水溶性壳聚糖和草药蜂蜜（AMCH）的抗菌保湿霜来治疗AD样病变。通过感觉评分、抓挠行为、血液中免疫细胞、血清IgE水平、肥大细胞浸润和皮肤组织学检查，评估AMCH对1-氯-2,4-二硝基苯（DNCB）诱导的NC/Nga小鼠AD样病变的抑制作用。 AMCH显着降低AD小鼠模型的感觉总分、抓挠行为、血清IgE、白细胞介素4（IL-4）和IL-12水平。此外，其抑制作用导致肥大细胞浸润减少。我们的结果表明，AMCH 作为治疗 AD 样病变的有效药物可能是有益的。
Atopic dermatitis (AD) is a chronic inflammatory skin disease that was influenced by complex interactions via genetic, environmental, immunologic, and biochemical factors, though the cause of AD is still unknown. It characterized by elevated serum immunoglobulin E (IgE) levels, immunological abnormalities, and eosinophilia in the tissues and peripheral blood. In the present study, we applied an antimicrobial moisturizing cream containing low-molecular weight water-soluble chitosan and herbal honey (AMCH) to remedy AD-like lesions. The inhibiting effect of AMCH on NC/Nga mice, that AD-like lesion was induced by 1-chloro-2,4-dinitrobenzene (DNCB), was evaluated by examining sensory evaluation scores, scratching behavior, immune cells in blood, serum IgE level, infiltration of mast cells, and skin histology. The total sensory evaluation scores, scratching behavior, the level of serum IgE, interlukin-4 (IL-4), and IL-12 in AD mouse model were significantly reduced by AMCH. Moreover, its suppressing effect resulted in decreased mast cell infiltration. Our results suggest that AMCH might be beneficial as a potent agent for treatment of AD-like lesion.