12-YEAR INCIDENCE OF CORONARY HEART-DISEASE IN MIDDLE-AGED ADULTS DURING THE ERA OF HYPERTENSIVE THERAPY - THE FRAMINGHAM OFFSPRING STUDY
12-YEAR INCIDENCE OF CORONARY HEART-DISEASE IN MIDDLE-AGED ADULTS DURING THE ERA OF HYPERTENSIVE THERAPY - THE FRAMINGHAM OFFSPRING STUDY
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DOI：
10.1016/0002-9343(91)90500-w
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发表时间：
1991-01-01
影响因子：
5.9
通讯作者：
CASTELLI, WP
中科院分区：
文献类型：
--
作者：
WILSON, PWF;ANDERSON, KM;CASTELLI, WP
目的：提供有关弗雷明汉心脏研究原始队列后代冠心病（CHD）发病率的信息。患者和方法：从1972年到1974年，弗雷明汉心脏研究原始参与者的后代接受了标准心血管危险因素的基线检查。在研究开始时，这些后代年龄在30至59岁之间，没有冠心病。他们被跟踪了12年，在此期间，1663名男性中的156名和1714名女性中的55名患上了冠心病。结果：在多变量比例风险模型中，冠心病与年龄、较低的高密度脂蛋白胆固醇（HDL-C）水平和吸烟数量显著相关。在男性中，空腹血糖水平和低密度脂蛋白胆固醇（LDL-C）与冠心病高度相关，但在女性中处于临界状态，而在调整HDL-C和葡萄糖后，甘油三酯和极低密度脂蛋白胆固醇与冠心病没有显著相关性。一半的高血压患者使用降压药，只有女性的收缩压与冠心病有关。结论：本研究证实了吸烟和LDL-C这两个常见的冠心病危险因素的重要性，并扩展了HDL-C在中年队列中的预后作用。在这项研究中，无论是否使用降压药，血压的影响都有所降低，数据表明这种降低是由于治疗成功。
PURPOSE: To provide information on the incidence of coronary heart disease (CHD) in the offspring of the original cohort from the Framingham Heart Study.PATIENTS AND METHODS: From 1972 to 1974, offspring of the original participants in the Framingham Heart Study underwent a baseline examination for standard cardiovascular risk factors. At entry into the study, these offspring were 30 to 59 years old and free of CHD. They were followed for 12 years, during which time 156 of 1,663 men and 55 of 1,714 women developed CHD.RESULTS: In a multivariate proportional hazards model, CHD was significantly associated with age, lower high-density lipoprotein cholesterol (HDL-C) levels, and number of cigarettes smoked. Fasting glucose levels and low-density lipoprotein cholesterol (LDL-C) were highly associated with CHD in men, but borderline in women, while triglycerides and very-low-density lipoprotein cholesterol were not significantly associated with CHD after adjustment for HDL-C and glucose. Blood pressure medication was used in half of the hypertensive individuals, and systolic pressure was associated with CHD in women only.CONCLUSIONS: This study confirms the importance of the common CHD risk factors of cigarette smoking and LDL-C, and extends the prognostic role of HDL-C in a middle-aged cohort. The impact of blood pressure, with or without use of hypertensive medications, was reduced in this study, and the data suggest that this attenuation was due to successful treatment.