Increased level of serum cytokines, chemokines and adipokines in patients with schizophrenia is associated with disease and metabolic syndrome
Increased level of serum cytokines, chemokines and adipokines in patients with schizophrenia is associated with disease and metabolic syndrome
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DOI：
10.1016/j.psyneuen.2012.04.001
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发表时间：
2012-12-01
影响因子：
3.7
通讯作者：
Cohen, Dan
中科院分区：
文献类型：
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作者：
Beumer, Wouter;Drexhage, Roosmarijn C.;Cohen, Dan
目前，有强烈的迹象表明，精神分裂症(SZ)、糖尿病和代谢综合征(METS)有共同的易感性因素。本研究以单核/巨噬细胞系统异常激活为共同因子，检测144例SZ患者血清单核/巨噬细胞细胞因子/趋化因子/脂肪因子CCL2、CCL4、IL-1β、TNF-α、IL-6、PTX3、瘦素、脂联素、PAI-1、OPG和ICAM-1水平，并与健康对照组(HC)(n=138)进行比较。通过多因素分析，我们研究了疾病SZ的存在、包括BMI在内的蛋氨酸成分、血脂水平(高密度脂蛋白胆固醇和甘油三酯)、糖尿病(高血糖)和抗精神病药物的使用对这些免疫化合物水平的影响。我们发现，除PAI-1和OPG外，所有检测到的免疫化合物在SZ患者群体中均升高。多因素分析显示，升高与性别(ICAM-1、瘦素、肿瘤坏死因子-α和脂联素)、体重指数(瘦素、脂联素)、高血糖/糖尿病(CCL4和OPG)、降低高密度脂蛋白胆固醇或升高甘油三酯(脂联素和PTX3)或蛋氨酸(CCL2、瘦素和脂联素)水平有关。IL-1β和IL-6是患者血清中仅有的不受任何纳入因素影响的免疫化合物。尽管许多免疫化合物被发现与蛋氨酸(成分)有关，但与精神分裂症的联系最明显，证实了早先的报道，即单核/巨噬细胞激活增加是理解精神分裂症发病机制的关键成分。版权所有(C)2012爱思唯尔有限公司。保留所有权利。
At present there are strong indications of a shared vulnerability factor for schizophrenia (SZ), diabetes and the metabolic syndrome (metS). In this study we focus on an aberrantly activated monocyte/macrophage system as the shared factor.We measured in SZ patients (n=144), the serum levels of monocyte/macrophage cytokines/chemokines/adipokines CCL2, CCL4, IL-1 beta, TNF-alpha, IL-6, PTX3, leptin, adiponectin, PAI-1, OPG and ICAM-1 and compared these levels to healthy controls (HC) (n=138). Using multivariate analysis, we studied the effect of the presence of the disease SZ, the components of the metS including BMI, the levels of lipids (HDL cholesterol and triglycerides (TG)), diabetes (hyperglycemia) and the use of antipsychotic medication, on the serum levels of these immune compounds.We found all measured immune compounds with the exception of PAI-1 and OPG to be elevated in the SZ patient population. Multivariate analysis showed that elevations were linked to gender (ICAM-1, leptin, TNF-alpha and adiponectin), an increased BMI (leptin, adiponectin), hyperglycemia/diabetes (CCL4, and OPG), reduced HDL-cholesterol or increased levels of TG (adiponectin and PTX3) or the metS (CCL2, leptin and adiponectin). IL-1 beta and IL-6 were the only immune compounds raised in the serum of patients not affected by any of the included factors.Although many of the immune compounds were found linked to (components of) the metS, the most dominant linkage was found with the disease schizophrenia, confirming earlier reports on increased monocyte/macrophage activation as a key component for understanding the pathogenesis of schizophrenia. Copyright (C) 2012 Elsevier Ltd. All rights reserved.