Increased chemerin and decreased omentin-1 levels in morbidly obese patients are correlated with insulin resistance, oxidative stress and chronic inflammation.
Increased chemerin and decreased omentin-1 levels in morbidly obese patients are correlated with insulin resistance, oxidative stress and chronic inflammation.
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DOI：
10.15386/cjm.2014.8872.871.afc1
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Pop ID
中科院分区：
文献类型：
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作者：
Cătoi AF;Suciu Ş;Pârvu AE;Copăescu C;Galea RF;Buzoianu AD;Vereşiu IA;Cătoi C;Pop ID
病态肥胖代表与脂肪因子失调相关的促炎和促氧化状态。我们的目的是评估chemerin和omentin-1在病态肥胖（MO）患者的循环水平，并调查这两个脂肪因子之间的关系，他们之间的人体测量，代谢，氧化应激和慢性炎症参数。本研究对32例MO患者和20例对照者进行了调查。测量人体测量、代谢参数、炎症标志物、氧化应激指标以及chemerin和omentin-1。与对照组相比，MO患者血清chemerin水平升高，而omentin-1水平降低。Chemerin与胰岛素、HOMA-IR、LDL胆固醇呈正相关，与总抗氧化反应呈负相关。网膜素-1与肿瘤坏死因子α和总胆固醇呈负相关。在多元线性逐步回归分析中，我们了解到只有HOMA-IR（β=0.70，p<0.001）、总胆固醇（β=0.42，p<0.001）和甘油三酯（β=0.31，p<0.05）与chemerin变化显著相关。使用相同的分析，我们注意到总胆固醇（β=-0.71，p<0.001），空腹血糖（β=-0.40，p<0.05）和体重指数（BMI）（β=-0.38，p<0.05）被认为是网膜蛋白-1变化的重要预测因子。在MO患者中，Chemerin和omentin-1的合成失调。Chemerin可能在胰岛素抵抗和氧化应激中发挥作用。Chemerin的变化似乎主要由胰岛素抵抗预测。Omentin-1水平与慢性炎症和血脂异常呈负相关，而主要调节因素似乎是血脂异常、高血糖和BMI。
Morbid obesity represents a proinflammatory and pro-oxidative state associated with dysregulation of adipokines. We aimed to evaluate the circulating levels of chemerin and omentin-1 in morbidly obese (MO) patients and to investigate the relationship between these two adipokines and between each of them and anthropometric, metabolic, oxidative stress and chronic inflammatory parameters. 32 MO patients and 20 controls were investigated in this study. Anthropometric, metabolism parameters, inflammatory markers, oxidative stress indicators as well as chemerin and omentin-1 were measured. Serum levels of chemerin were increased while omentin-1 levels were decreased in MO patients when compared with controls. Chemerin correlated positively with insulin, HOMA-IR, LDL cholesterol and negatively with total antioxidant response. Omentin-1 correlated negatively with tumor necrosis factor alpha and total cholesterol. In a multiple linear stepwise regression analysis we learnt that only HOMA-IR (β=0.70, p<0.001), total cholesterol (β=0.42, p<0.001) and triglycerides (β=0.31, p<0.05) remained significantly associated with chemerin changes. Using the same analysis we noticed that total cholesterol (β=−0.71, p<0.001), fasting glucose (β= −0.40, p<0.05) and body mass index (BMI) (β= −0.38, p<0.05) were considered to be significant predictors for omentin-1 changes. Chemerin and omentin-1 synthesis was dysregulated in MO patients. Chemerin might play a role in insulin resistance and oxidative stress. Chemerin changes seemed to be predicted mainly by insulin resistance. Omentin-1 levels were inversely associated with chronic inflammation and dyslipidemia while the main modulating factors seemed to be dyslipidemia, hyperglycemia and BMI.