Regional outcomes of severe acute respiratory syndrome coronavirus 2 infection in hospitalised patients with haematological malignancy
Regional outcomes of severe acute respiratory syndrome coronavirus 2 infection in hospitalised patients with haematological malignancy
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DOI：
10.1111/ejh.13469
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发表时间：
2020-10-01
影响因子：
3.1
通讯作者：
Peniket, Andy
中科院分区：
文献类型：
--
作者：
Booth, Stephen;Willan, John;Peniket, Andy
目标 我们试图描述由 7 家医院组成的区域网络中患有血液系统恶性肿瘤和严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染的患者的结局特征。方法 确定2020年1月3日至2020年5月6日连续住院的血液系统恶性肿瘤和SARS-CoV-2感染患者。结果分为死亡、已解决或正在进行。主要结局是初步病死率（pCFR），定义为导致死亡的病例数占所有诊断病例的比例。分析主要是描述性的。结果 纳入 66 名患者，总体 pCFR 为 51.5%。 70岁以上的患者占住院病例（42例，63%）和死亡病例（25例，74%）的大部分。女性（52%）和男性（51%）的死亡率相似。诊断 SARS-CoV-2 感染后 3 个月内接受免疫抑制或细胞毒治疗与 pCFR 显着升高 70% 相关，而未接受积极治疗的患者的 pCFR 为 28%（P = 0.0013，2 比例检验）。结论 血液系统恶性肿瘤和 SARS-CoV-2 感染患者在院内的死亡率较高，是降低该人群感染风险的高支持措施。
Objectives We sought to characterise the outcomes of patients with haematological malignancy and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in hospital in our regional network of 7 hospitals. Methods Consecutive hospitalised patients with haematological malignancy and SARS-CoV-2 infection were identified from 01/03/2020 to 06/05/2020. Outcomes were categorised as death, resolved or ongoing. The primary outcome was preliminary case fatality rate (pCFR), defined as the number of cases resulting in death as a proportion of all diagnosed cases. Analysis was primarily descriptive. Results 66 Patients were included, overall pCFR was 51.5%. Patients >= 70 years accounted for the majority of hospitalised cases (42, 63%) and fatalities (25, 74%). Mortality was similar between females (52%) and males (51%). Immunosuppressive or cytotoxic treatment within 3 months of the diagnosis of SARS-CoV-2 infection was associated with a significantly higher pCFR of 70%, compared with 28% in those not on active treatment (P = .0013, 2 proportionsztest). Conclusions Mortality rates in patients with haematological malignancy and SARS-CoV-2 infection in hospital are high supporting measures to minimise the risk of infection in this population.