Controlled Rupture of Magnetic Polyelectrolyte Microcapsules for Drug Delivery
Controlled Rupture of Magnetic Polyelectrolyte Microcapsules for Drug Delivery
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DOI：
10.1021/la801138e
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发表时间：
2008-10-21
期刊：
影响因子：
3.9
通讯作者：
Chen, San-Yuan
中科院分区：
文献类型：
--
作者：
Hu, Shang-Hsiu;Tsai, Chia-Hui;Chen, San-Yuan
本研究以Fe 3 O 4/聚烯丙基胺（Fe 3 O 4/PAH）为壳层，制备了磁敏微胶囊。系统地研究了荧光染料和阿霉素的结构完整性、微观结构演变以及相应的释放行为。实验观察表明，在壳结构中的磁性纳米颗粒的存在下，允许壳结构从纳米腔发展到壳的最终破裂，在给定的不同持续时间的磁刺激下。磁敏壳结构的这种微观结构演变解释了药物释放曲线的相应变化，从相对缓慢的释放到不同刺激阶段的爆发状行为。有人提出，磁性纳米粒子的存在产生热量，由于磁能耗散（布朗和尼尔松弛），机械振动和运动，诱导应力的发展薄壳。这两种机制都显著加速了壳结构的松弛，导致了这种微观结构的演变。通过磁敏壳结构的这种可控的微结构演变，可以根据磁场下的持续时间以可管理的方式利用可设计的分布来良好地调节活性物质。细胞培养研究还表明，磁敏感微胶囊允许被癌细胞系A549细胞系快速摄取，这表明具有可控破裂行为的壳的磁敏感微胶囊提供了用于抗癌应用的潜在且有效的药物载体。
In this study, a magnetic-sensitive microcapsule was prepared using Fe3O4/poly(allylamine) (Fe3O4/PAH) polyelectrolyte to construct the shell. Structural integrity, microstructural evolution, and corresponding release behaviors of fluorescence dyes and doxorubicin were systematically investigated. Experimental observations showed that the presence of the magnetic nanoparticles in the shell structure allowed the shell structure to evolve from nanocavity development to final rupture of the shell under a given magnetic stimulus of different time durations. Such a microstructural evolution of the magnetic sensitive shell structure explained a corresponding variation of the drug release profile, from relatively slow release to burst-like behavior at different stages of stimulus. It has proposed that the presence of magnetic nanoparticles produced heat, due to magnetic energy dissipation (as Brown and Neel relaxations), and mechanical vibration and motion that induced stress development in the thin shell. Both mechanisms significantly accelerated the relaxation of the shell structure, causing such a microstructural evolution. With such a controllable microstructural evolution of the magnetic-sensitive shell structure, active substances can be well-regulated in a manageable manner with a designable profile according to the time duration under magnetic field. A cell culture study also indicated that the magnetic-sensitive microcapsules allowed a rapid uptake by the A549 cell line, a cancerous cell line, suggesting that the magnetic-sensitive microcapsule with controllable rupturing behavior of the shell offers a potential and effective drug carrier for anticancer applications.