Tooth loss associated with the use of tenofovir disoproxil fumarate
Tooth loss associated with the use of tenofovir disoproxil fumarate
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DOI：
10.1111/jcpt.13219
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发表时间：
2020-08-21
影响因子：
2
通讯作者：
Wang Bin
中科院分区：
文献类型：
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作者：
Long Jianfei;Li Ling;Wang Bin
富马酸替诺福韦二氧吡酯（TDF）相关的常见不良反应（adr）有肾毒性和骨毒性；然而，TDF与牙齿相关的不良反应尚未见报道。我们报告了一例41岁汉族男性慢性乙型肝炎伴tdf相关牙齿脱落的病例。患者使用TDF后出现口臭、牙龈肿胀和牙齿脱落。在排除了其他药物相关不良反应的可能性后，TDF被认为是一个可能的原因，并改用富马酸替诺福韦阿拉胺（TAF）。6个月后，口腔症状消失，无额外的牙齿脱落。这是关于此类adr的首次报告。ADR得分为7分，表明牙齿脱落是潜在的tdf相关ADR。
What is known and objective The frequent tenofovir disoproxil fumarate (TDF)-related adverse drug reactions (ADRs) are nephrotoxicity and bone toxicity; however, tooth-related ADRs of TDF have not been reported. We describe the case of a 41-year-old Han Chinese man with chronic hepatitis B with TDF-associated tooth loss. Case summary He presented with halitosis, gingival swelling and tooth loss after TDF use. After excluding the possibility of other drug-related ADRs, TDF was considered a possible cause and switched with tenofovir alafenamide fumarate (TAF). After 6 months, the oral symptoms disappeared, with no additional tooth loss. What is new and conclusion This is the first report of such ADRs. The ADR score was 7, indicating tooth loss as a potential TDF-related ADR.