Antibiotic Use in Suspected and Confirmed COVID-19 Patients Admitted to Health Facilities in Sierra Leone in 2020-2021: Practice Does Not Follow Policy.
Antibiotic Use in Suspected and Confirmed COVID-19 Patients Admitted to Health Facilities in Sierra Leone in 2020-2021: Practice Does Not Follow Policy.
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DOI：
10.3390/ijerph19074005
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发表时间：
2022-03-28
影响因子：
--
通讯作者：
Zachariah R
中科院分区：
文献类型：
--
作者：
Kamara IF;Kumar AMV;Maruta A;Fofanah BD;Njuguna CK;Shongwe S;Moses F;Tengbe SM;Kanu JS;Lakoh S;Mansaray AHD;Selvaraj K;Khogali M;Zachariah R
新冠肺炎大流行期间抗生素的不当使用有可能增加抗菌素耐药性的负担。在这项研究中，我们报告了2020年3月至2021年3月在塞拉利昂35家医疗机构住院的疑似和确诊的新冠肺炎患者中抗生素使用的流行率及其相关因素。这是一项使用常规收集的患者数据的横断面研究。在700名确诊的新冠肺炎患者中，47%的患者接受了抗生素治疗。大多数(73%)的抗生素属于“WATCH”类抗生素，这种抗生素毒性大，容易产生耐药性。最常用的抗生素是阿奇霉素、头孢曲松、阿莫西林、甲硝唑和阿莫西林-克拉维酸。在25-34岁的患者中，抗生素的使用量明显高于那些患有严重疾病的患者。在7，55名疑似新冠肺炎患者中，61%的患者接受了抗生素治疗，其中大多数(58%)属于“观察”类别。最常用的抗生素是头孢曲松、甲硝唑、阿奇霉素、环丙沙星和阿莫西林。在塞拉利昂医疗机构住院的疑似和确诊新冠肺炎患者中，抗生素的使用率很高，不符合国家和世卫组织病例管理指南。迫切需要对卫生保健提供者进行培训，加强抗菌素管理方案和微生物实验室能力。
Inappropriate use of antibiotics during the COVID-19 pandemic has the potential to increase the burden of antimicrobial resistance. In this study, we report on the prevalence of antibiotic use and its associated factors among suspected and confirmed COVID-19 patients admitted to 35 health facilities in Sierra Leone from March 2020–March 2021. This was a cross-sectional study using routinely collected patient data. Of 700 confirmed COVID-19 patients, 47% received antibiotics. The majority (73%) of the antibiotics belonged to the ’WATCH’ group of antibiotics, which are highly toxic and prone to resistance. The most frequently prescribed antibiotics were azithromycin, ceftriaxone, amoxicillin, metronidazole, and amoxicillin-clavulanic acid. Antibiotic use was significantly higher in patients aged 25–34 years than in those with severe disease. Of 755 suspected COVID-19 patients, 61% received antibiotics, of which the majority (58%) belonged to the ‘WATCH’ category. The most frequently prescribed antibiotics were ceftriaxone, metronidazole, azithromycin, ciprofloxacin, and amoxycillin. The prevalence of antibiotic use among suspected and confirmed COVID-19 patients admitted to healthcare facilities in Sierra Leone was high and not in line with national and WHO case management guidelines. Training of health care providers, strengthening of antimicrobial stewardship programs, and microbiological laboratory capacity are urgently needed.
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影响因子：
34.3
作者：
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通讯作者：
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影响因子：
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158.5
作者：
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通讯作者：
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影响因子：
3.7
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通讯作者：
SEMI-COVID-19 Network